Page< 4 03 KMnO4 Li/NH3 1. NaNH2 2. CH3l Q10. Apply retrosynthetic analysis to design a synthesis of the compound below, starting an alkyne and an alkyl halide. Q9. Complete these following transformations: H₂ Lindlar' reduction 03 KMnO4 Page
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- (h) CHCO CI CH3CO2H, 50 °C Draw the major product(s) of the reaction.The key step in a reported laboratory synthesis of sativene, a hydrocarbon isolated from the mold Helminthosporium sativum, involves the following base treatment of a keto tosylate. What kind of reaction is occurring? How would you complete the synthesis?OIV OV What is the predicted product of the elimination reaction shown? IV OH HO conc. H2SO4 heat || V III
- What is an appropriate stepwise synthesis for the reaction shown? O1. HBr; 2. NaH; 3. CH3CH₂1 O 1. BH3-THF followed by H₂O2/NaOH/H₂O; 2. CH3CH₂1 O 1. BH3-THF followed by H₂O2/NaOH/H₂O; 2. NaH; 3. CH3CH₂1 1. BH3-THF followed by H₂O2; 2.. NaH; 3. CH3l O1. Br₂ followed by H₂O2/NaOH/H₂O; 2. NaH; 3. CH3CH₂lDraw the final product formed in the reaction below.For each, draw the organic product (ignoring stereochemistry), and state whether the process is overall oxidation, overall reduction, or neither.
- Identify the suitable reagents for the given reaction and arrange them accordingly. 1 OH OEt 2 OEt OEt O 1) EtOH, H₂SO4; 2) EtOH, H₂SO4 O 1) EtONa followed by H₂O; 2) TsCl/py followed by EtONa O 1) EtONa followed by H₂O; 2) NaH followed by EtBr O 1) EtOH, H₂SO4; 2) NaH followed by EtBr O 1) EtOH, H₂SO4; 2) TsCy followed by EtONa1. What is the principal product of the following Hofmann rearrangementDraww all possible organic products and kinds of reactions (SN1, SN2, E1, E2)
- 4. Regioselectivity Draw the major product formed for each reaction. Assume the reactions are irreversible. Include stereochemistry when products contain stereocenter(s). (a) Draw only the substitution product. Both elimination and substitution occur here. Hac Br CH₂OH (c) (b) CH3 CH3 Br H NaOCH3 80 °C 1 equiv CH3Li thenhelp with b pleaseWhich set of reagents would be appropriate to synthesize bromobenzene from benzene? O 1. HNO3 in H2SO4; 2. H2CrO4 and heat O 1. H2CrO4 and heat; 2. H2 Pd/C O Br2 and FeBr3 O 1. CH3CH2CHCI and AICI3; 2. H2CRO4 and heat O4B12 and Fe O Heat and Br2 OBR2, HCI