**Q4.10**. A cell has been exposed to a poison that stops ligase from working. If all other enzymes are functioning normally, the cell will reach a certain point in DNA replication but then be unable to proceed further. At that point, what will the cell's replication bubble look like? (Note: In the figures, DNA is black, RNA is red, and only half of each bubble is shown.)Here are the four figures representing possible states of the replication bubble:- **Figure A** - Description: Represents a simple Y-shaped structure with two divergent black lines (indicating DNA). No red lines (representing RNA) are present. - **Figure B** - Description: Similar to Figure A but with small red segments (indicating RNA) attached to the black lines near the replication fork. - **Figure C** - Description: Features black lines (DNA) forming the main structure, but with more extensive red segments (RNA) interspersed throughout the diverging ends. - **Figure D** - Description: Only black lines (DNA) forming the primary structure, ending with no red segments (RNA).**Explanation:**- The question requires identification of the replication bubble's appearance when ligase is inhibited and other enzymes are functioning typically.- Ligase is responsible for sealing nicks in the DNA, especially important in Okazaki fragments during lagging-strand synthesis.- Since RNA primers must be laid down and extended by DNA polymerase before ligase seals any gaps, an inhibition of ligase while other systems are functional would suggest an accumulation of unsealed Okazaki fragments represented by segments of RNA interspersed between DNA. Therefore, in the absence of ligase activity, the replication bubble would most closely resemble **Figure C**, where RNA primers remain present.

Name: **Q4.10**. A cell has been exposed to a poison that stops ligase from
Uploaded: 2024-03-20T06:42:41.000Z
Channel: Bartleby
Description: **Q4.10**. A cell has been exposed to a poison that stops ligase from working. If all other enzymes are functioning normally, the cell will reach a certain point in DNA replication but then be unable to proceed further. At that point, what will the