Plata concentationAY--A new drug was administered intravenously, and its plasma levels weremeasured for several hours. A graph was prepared as shown above, withthe plasma levels plotted on a logarithmic ordinate and time on a linearabscissa. It was concluded that the drug has first-order kinetics. From thisgraph, what is the best estimate of the half-life?Lütfen birini seçin:a. 3 hb. 0,5 hc. 7 hd. 4 h. 1 h concntimeWhich statement is a possible result to obtain this time-concentration curve of two drugs named as "White and Black"?Lütfen birini seçin:a. Elimination phase of White is faster than Blackb. There is a delay in gastric emptying of drug White relatedto absorptionc. There is a big difference between the peak concentrationof White and Blackd. There is a delay in gastric emptying of drug Black relatedto absorptione. If dosage form of White is oral, the dosage form of Blackis IV injection

A few important terms:Intravenous: The drug is injected as a bolus or infused slowly over hours in…

Answered: Puter A new drug was administered…

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3a) An 68 kg patient is to be given a 2.0 mg/kg body weight IV bolus dose of a newly developed antibiotic drug every 6 hours. Assume the half-life of the drug and its volume of distribution in the patient are 3.2 hours and 0.26 L/kg respectively. (a) Calculate the peak and trough plasma concentrations for the antibiotic after, one dose, two doses, four doses, and at steady state.
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A company has formulated their drug into a salt using the reaction below. A medical student would like to know possible reasons for making this salt. You explain that the new salt could have been made into different products to: (SELECT ALL THAT APPLY) HO Drug X Currently Selected: A, B - A improve oral palatability (improve taste). B formulate an IV injection, C make a long acting IM depot injection D make a lipid soluble supsension for pediatric formulation S O
Various concentrations of recombinant human insulin were prepared for use standards for an HPLC method. To verify the prepared concentrations, the samples were analyzed by measuring the absorbance at 280 nm in a short path length (5 mm) cuvette. The molar absorption coefficient for human insulin is approximately 5.875 x 10³ M-¹cm-¹. a. Calculate the extinction coefficient in mL mg-¹cm-¹. b. Calculate the concentrations of the following human insulin standards if the measured absorbances and dilutions used are: Standard 1 Standard 2 Abs. (at 280 nm) of Diluted Sample 0.305 0.685 Dilution 145.0 µL sample, 25.0 μL buffer 130.0 µL sample, 40.0 μL buffer
Calculate the following dosage: A doctor's prescription for pepcid is 15.5 mg per kg of body weight per dose. For an adult who weighs 135 lbs, calculate the number of grams to be given in a dose.
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You are presented with the following prescription: Rx Drug Y 175 mg Witepsol H15 q.s. Supply 6 suppositories (using 3 g nominal moulds) When using Witepsol H15, moulds will hold 1.06 times their nominal weight. The displacement value of Drug Y in Witepsol H15 is 1.1. Calculate the mass of Witepsol H15 required to prepare this product. Give your answer to two decimal places.
Answer the questions based on the data table. [s] mM 0.333 0.40 0.50 0.666 1.0 2.0 V (M/s) Uninhibited 1.65 x 107 1.86 x 107 2.13 x 107 2.49 x 107 2.99 x 107 3.72 x 107 V (M/s) x 107 Inhibitor A 1.05 x 107 1.21 x 107 1.43 x 107 1.74 x 107 2.22 x 107 3.08 x 107 Determine the Km and Vmax of the enzyme. Determine the type of inhibition imposed by inhibitor A. Determine the type of inhibition imposed by inhibitor B. V (M/s) x 107 Inhibitor B 0.794 x 107 0.893 x 107 1.02 x 107 1.19 x 107 1.43 x 107 1.79 x 107
A doctor wants to prescribe a 70 kg patient a drug to be taken PO. In order to achieve an average steady-state plasma concentration (Css) of this drug in its therapeutic range, the patient needs to have a of Css of 597 μg/L. The VD of this drug is 2.3 L/kg, the F of this drug is 0.70, and the half-life of this drug is 12.9 hours. What is the necessary dosing regimen needed to achieve the desired Css? (units: mg/day, i.e., mg/24 h))
Calculate doses for the drugs indicated below based on the patient's BSA. Calculate the BSA to the nearest hundredth and medication dosages to the nearest tenth. Show complete solutions. 1. An adult who is 68.8 kg and 165 cm needs monthly IV doses of cyclophosphamide for cancer treatment. The recommended monthly dose is 0.5 to 1 g/m2. What is the dose appropriate for this patient? a. If the lowest dose is ordered and cyclophosphamide for IV administration is available as 100 mg/5 mL, how many mL of medication would be added to IV fluid for infusion each month?
A 10-week-old child suffered from a salt-wasting crisis. His adrenal glands were enlarged and other organs were normal size. The child is phenotypically female, karotyping showed that the child is 46XY. The biochemical profile shows as: - sodium of 109 (reference range: 134-147) - potassium of 6.1 (reference range: 3.5-5.0) - pregnenlone of 0.002 (reference range: 0.3-1.5) - renin activity of 38 (reference range: 0.5-3.5) - 17-OH pregnenolone of 0.01 (reference range: 6.8-93.5) - ACTH of 1960 (reference range: 0.5-3.5) The cholesterol esters in the adrenal glands accumulated and the concentration of ∆4-androstenedione was not detectable. Also, the enzymes in the steroid biosynthesis did not have detrimental mutations. The child was given treatment with glucocorticoid and mineralocorticoid. Question: a) Which protein is deficient in this case and explain the rationale.
Consider a pH titration curve at 298 K for 50 mL of 0.10 M hypobromous acid, HBrO (Ka = 2.8 x 10−9), titrated with 0.10 M KOH solution. a. What volume of KOH is needed to reach the half-equivalence point? b. Calculate the pH of the HBrO sample at the half-equivalence point. c. Calculate the equivalence point pH. d. Identify a satisfactory pH indicator for the equivalence point. The pH range of colour change is indicated in parentheses. A) Methyl orange (3.0 - 4.3) B) Bromocresol purple (5.0 - 6.5) C) Alizarin yellow R (10.0 - 12.0) D) Methyl red (4.2 - 6.2)

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