Protein Domain Mutations A) abasic nt endonuclease DNA-binding domain B) DNA gyrase C) DNA helicase D) DNA ligase E) DNA phytolase F) 5' exonuclease G) ExoI Asp to Ala Arg to Glu Gln to Asn Ala to His dimerization domain ATPase domain Ligation domain DNA-binding domain Ile to Ala nuclease domain Trp to Ala Gln to Asn nuclease domain H) EXOVII I) Gamma complex J) MSH proteins nuclease domain ATPase domain DNA-binding domain nuclease domain Arg to Pro Trp to Ala Asp to Ala Met to Tyr K) MutH L) Muts DNA-binding domain methyltransferase domain glycosylase domain RNA binding domain DNA binding domain DNA binding domain Thumb domain Palm domain Phe to Ala Ala to Asp M) 06-methyltransferase N) oxoG glycosylase 0) Primase P) Pol delta Q) Pol epsilon R) Pol III S) Pol III T) Pol III U) Pol IV V) RNase H Gln to Asn Met to Tyr Ile to Ala Gln to Asn Asp to Ala Asp to Ala Asp to Ala Ile to Ala Fingers domain DNA binding domain nuclease domain nuclease domain Phe to Ala W) RecJ X) Sliding Clamp Y) SSB 2) SSB AA) Tao protein AB) Tao protein AC) Uracil glycosylase binding domain DNA binding domain DNA binding domain protein binding domain protein binding domain glycosylase domain protein binding domain protein binding domain protein binding domain Ala to Asp Gln to Asn Arg to Lys Arg to Pro Ala to Asp Gln to Asn Met to Tyr Trp to Ala Asp to Ala Ala to Asp AD) UvrA AE) UvrD AF) XP Proteins

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Match the following phenotypes with the mutation that would be the most likely to be its cause.  The mutant proteins are listed below, followed by the protein domain that is mutated in each case, followed by the amino acid change that is a result of the mutation. 

  1. __ DNA replication in E.coli stops after one replication cycle, and the new DNA strands contain a large number of individual RNA nucleotides spaced throughout the newly synthesized strand.
  2. __ An E.coli mutant shows normal replication rates early I DNA replication, but the stops replicating DNA and is unable to continue.
  3. __ A mutant human cell line is unable to identify mutations occurring at times when the DNA is not being replicated.
  4. __ An E.coli mutant shows high mutation rates after DNA replication, and you observe fragments of methylated DNA cut out from the newly-synthesized chromosome.
Protein
Domain
Mutations
Asp to Ala
Arg to Glu
Gln to Asn
A)
abasic nt endonuclease
DNA-binding domain
B) DNA gyrase
dimerization domain
C)
DNA helicase
ATPase domain
D) DNA ligase
DNA phytolase
F) 5' exonuclease
G) ExoI
Ligation domain
Ala to His
E)
DNA-binding domain
Ile to Ala
Trp to Ala
Gln to Asn
nuclease domain
nuclease domain
Arg to Pro
Trp to Ala
Asp to Ala
Met to Tyr
nuclease domain
H)
Gamma complex
I)
J) MSH proteins
ExoVII
ATPase domain
DNA-binding domain
K) MutH
nuclease domain
DNA-binding domain
methyltransferase domain
glycosylase domain
RNA binding domain
DNA binding domain
DNA binding domain
L) MutS
Phe to Ala
M) 06-methyltransferase
N) oxoG glycosylase
0) Primase
P) Pol delta
Q) Pol epsilon
R) Pol III
Ala to Asp
Gln to Asn
Met to Tyr
Ile to Ala
Gln to Asn
Asp to Ala
Asp to Ala
Asp to Ala
Ile to Ala
Thumb domain
S)
Pol III
Palm domain
Fingers domain
DNA binding domain
T) Pol III
U) Pol IV
V) RNase H
nuclease domain
Phe to Ala
W) RecJ
nuclease domain
Ala to Asp
binding domain
DNA binding domain
DNA binding domain
protein binding domain
protein binding domain
glycosylase domain
protein binding domain
protein binding domain
protein binding domain
Gln to Asn
X) Sliding Clamp
Y) SSB
Z) SSB
AA) Tao protein
AB) Tao protein
AC) Uracil glycosylase
Arg to Lys
Arg to Pro
Ala to Asp
Gln to Asn
Met to Tyr
Trp to Ala
Asp to Ala
Ala to Asp
AD) UvrA
AE) UvrD
AF) XP Proteins
Transcribed Image Text:Protein Domain Mutations Asp to Ala Arg to Glu Gln to Asn A) abasic nt endonuclease DNA-binding domain B) DNA gyrase dimerization domain C) DNA helicase ATPase domain D) DNA ligase DNA phytolase F) 5' exonuclease G) ExoI Ligation domain Ala to His E) DNA-binding domain Ile to Ala Trp to Ala Gln to Asn nuclease domain nuclease domain Arg to Pro Trp to Ala Asp to Ala Met to Tyr nuclease domain H) Gamma complex I) J) MSH proteins ExoVII ATPase domain DNA-binding domain K) MutH nuclease domain DNA-binding domain methyltransferase domain glycosylase domain RNA binding domain DNA binding domain DNA binding domain L) MutS Phe to Ala M) 06-methyltransferase N) oxoG glycosylase 0) Primase P) Pol delta Q) Pol epsilon R) Pol III Ala to Asp Gln to Asn Met to Tyr Ile to Ala Gln to Asn Asp to Ala Asp to Ala Asp to Ala Ile to Ala Thumb domain S) Pol III Palm domain Fingers domain DNA binding domain T) Pol III U) Pol IV V) RNase H nuclease domain Phe to Ala W) RecJ nuclease domain Ala to Asp binding domain DNA binding domain DNA binding domain protein binding domain protein binding domain glycosylase domain protein binding domain protein binding domain protein binding domain Gln to Asn X) Sliding Clamp Y) SSB Z) SSB AA) Tao protein AB) Tao protein AC) Uracil glycosylase Arg to Lys Arg to Pro Ala to Asp Gln to Asn Met to Tyr Trp to Ala Asp to Ala Ala to Asp AD) UvrA AE) UvrD AF) XP Proteins
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