Propose a synthetic route for the following transformations. If more than one step is necessary, show the product of each step. Do not show mechanism. You may choose to use the reagents from the reagent bank, but not required. Reagent Bank HCI SOCI2 H30*/heat MCPBA PBR3 Mg РСС BrMg 1. Hg(OAc)2 1. Br2/H2O 2. NaOH TsCl/Pyrdine KO'Bu 1. В13-THF 2. NaBH4 2. NAOH, H2O2 NaBH4 TMSCI/Pyridine Brz NaOMe H2/Pd NaOH а. ÓH
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
Organic reaction mechanisms
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