PROBLEM 1: A man with a hitchhikers thumb (Hh) and his wife who also has a hitchhikers thumn (Hh) are expecting a child. Use a Punnett square for your solution. a. What is the probability that the child will also have a hitchhikers thumb? b. What is the genotypic ratio? c. What is the phenotypic ratio? d. PUNNETT SQUARE

PROBLEM 1: A man with a hitchhikers thumb (Hh) and his wife who also has a hitchhikers thumn (Hh) are expecting a child. Use a Punnett square for your solution. a. What is the probability that the child will also have a hitchhikers thumb? b. What is the genotypic ratio? c. What is the phenotypic ratio? d. PUNNETT SQUARE

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Description: PROBLEM 1:A man with a hitchhikers thumb (Hh) and his wife who also has a hitchhikersthumn (Hh) are expecting a child. Use a Punnett square for your solution.a. What is the probability that the child will also have a hitchhikers thumb?b. What is the

Curren'S Math For Meds: Dosages & Sol

11th Edition

ISBN:9781305143531

Author:CURREN

Publisher:CURREN

Chapter15: Adult And Pediatric Dosages Based On Body Weight

Section: Chapter Questions

Problem 41SST

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Mitochondrial Mutations

A mitochondrion is a cellular organelle that serves as the site for cellular respiration and energy production (ATP or Adenosine Triphosphate). It is a double-membrane-bound organelle and is only present in eukaryotic cells.

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PROBLEM 1:
A man with a hitchhikers thumb (Hh) and his wife who also has a hitchhikers
thumn (Hh) are expecting a child. Use a Punnett square for your solution.
a. What is the probability that the child will also have a hitchhikers thumb?
b. What is the genotypic ratio?
c. What is the phenotypic ratio?
d. PUNNETT SQUARE

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A couple was referred for genetic counseling because they wanted to know the chances of having a child with dwarfism. Both the man and the woman had achondroplasia (MIM 100800), the most common form of short-limbed dwarfism. The couple knew that this condition is inherited as an autosomal dominant trait, but they were unsure what kind of physical manifestations a child would have if it inherited both mutant alleles. They were each heterozygous for the FGFR3 (MIM 134934) allele that causes achondroplasia. Normally, the protein encoded by this gene interacts with growth factors outside the cell and receives signals that control growth and development. In achrodroplasia, a mutation alters the activity of the receptor, resulting in a characteristic form of dwarfism. Because both the normal and mutant forms of the FGFR3 protein act before birth, no treatment for achrondroplasia is available. The parents each carry one normal allele and one mutant allele of FGRF3, and they wanted information on their chances of having a homozygous child. The counsellor briefly reviewed the phenotypic features of individuals with achondroplasia. These include facial features (large head with prominent forehead; small, flat nasal bridge; and prominent jaw), very short stature, and shortening of the arms and legs. Physical examination and skeletal X-ray films are used to diagnose this condition. Final adult height is approximately 4 feet. Because achondroplasia is an autosomal dominant condition, a heterozygote has a 1-in-2, or 50%, chance of passing this trait to his or her offspring. However, about 75% of those with achondroplasia have parents of average size who do not carry the mutant allele. In these cases, achondroplasia is due to a new mutation. In the couple being counseled, each individual is heterozygous, and they are at risk for having a homozygous child with two copies of the mutated gene. Infants with homozygous achondroplasia are either stillborn or die shortly after birth. The counselor recommended prenatal diagnosis via ultrasounds at various stages of development. In addition, a DNA test is available to detect the homozygous condition prenatally. What if the couple wanted prenatal testing so that a normal fetus could be aborted?
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