Please help with this homework assignment See image/PDF https://static.nsta.org/case_study_docs/case_studies/gwas_studies.pdf Part 3 What other factors will alter Josie’s risk of developing Alzheimer’s disease? Based on Josie’s genotype, what dose of warfarin would be best for her (high, low, or intermediate dose)? One of Josie’s favorite vegetables is asparagus. She noticed that she could detect a strong sulfur smell in her urine after eating asparagus. Explain why she is able to do this after looking at her data.
Please help with this homework assignment See image/PDF https://static.nsta.org/case_study_docs/case_studies/gwas_studies.pdf Part 3 What other factors will alter Josie’s risk of developing Alzheimer’s disease? Based on Josie’s genotype, what dose of warfarin would be best for her (high, low, or intermediate dose)? One of Josie’s favorite vegetables is asparagus. She noticed that she could detect a strong sulfur smell in her urine after eating asparagus. Explain why she is able to do this after looking at her data.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
Related questions
Question
Please help with this homework assignment
See image/PDF
https://static.nsta.org/case_study_docs/case_studies/gwas_studies.pdf
Part 3
-
What other factors will alter Josie’s risk of developing Alzheimer’s disease?
-
Based on Josie’s genotype, what dose of warfarin would be best for her (high, low, or intermediate dose)?
-
One of Josie’s favorite vegetables is asparagus. She noticed that she could detect a strong sulfur smell in her urine after eating asparagus. Explain why she is able to do this after looking at her data.
![Part III - Lab Results
Below is a partial list of Josie's results showing the gene that was tested, the chromosomal location of each gene and the
genotype of the SNPs within that gene.
Report
Variant tested
APOE (rs429358)
(rs7412)
VKORI (rs9923231)
CYP2C9 2 (rs1799853)
CYP2C9 3 (rs1057910)
Marker rs4481887
ALDH2 (rs671)
Genotype
CT
CC
AA
CC
AC
AA
AG
Chromosomal Location
19
19
16
NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE
10
10
12
"Living in a Genomic World" by Glaser and Zimmer
Phenotype/Risk
Questions
1. Using the information you learned about the various traits in Part II, fill in the final column of the chart above by
determining Josie's phenotype or risk based on her genotype. Explain how you interpreted the results.
a. What other factors will alter Josie's risk of developing Alzheimer's disease?
b. Based on Josie's genotype, what dose of warfarin would be best for her (high, low, or intermediate dose)?
c. One of Josie's favorite vegetables is asparagus. She noticed that she could detect a strong sulfur smell in her
urine after eating asparagus. Explain why she is able to do this after looking at her data.
d. By looking at the data, what does Josie's genotype tell you about her sensitivity to alcohol? Should this
information result in any behavior modifications?
2. Typically, genomic testing services group the traits they test for into categories such as (1) recessive disorders, (2)
drug response, (3) risk factors, and (4) non-health related traits. Consider the four traits mentioned in Part II
(Alzheimer's disease, warfarin sensitivity, asparagus metabolite detection, and alcohol flush reaction). In which
category does each trait belong?
3. Would you have liked to know your APOE status regardless of the results? Why or why not?
4. Do you think that Josie should be obligated to tell her family members the results? Why or why not? Would you
feel differently based on different APOE results? Would you feel differently if you were a carrier for a recessive
disease? If you had the allele for Huntington's disease, an autosomal dominant disorder characterized by progressive
neurodegeneration?
Page 10](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fc965a125-c22b-4b70-9710-62889e98676a%2Ff013959c-89ee-4a85-9456-1847db310963%2F0no7of7_processed.jpeg&w=3840&q=75)
Transcribed Image Text:Part III - Lab Results
Below is a partial list of Josie's results showing the gene that was tested, the chromosomal location of each gene and the
genotype of the SNPs within that gene.
Report
Variant tested
APOE (rs429358)
(rs7412)
VKORI (rs9923231)
CYP2C9 2 (rs1799853)
CYP2C9 3 (rs1057910)
Marker rs4481887
ALDH2 (rs671)
Genotype
CT
CC
AA
CC
AC
AA
AG
Chromosomal Location
19
19
16
NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE
10
10
12
"Living in a Genomic World" by Glaser and Zimmer
Phenotype/Risk
Questions
1. Using the information you learned about the various traits in Part II, fill in the final column of the chart above by
determining Josie's phenotype or risk based on her genotype. Explain how you interpreted the results.
a. What other factors will alter Josie's risk of developing Alzheimer's disease?
b. Based on Josie's genotype, what dose of warfarin would be best for her (high, low, or intermediate dose)?
c. One of Josie's favorite vegetables is asparagus. She noticed that she could detect a strong sulfur smell in her
urine after eating asparagus. Explain why she is able to do this after looking at her data.
d. By looking at the data, what does Josie's genotype tell you about her sensitivity to alcohol? Should this
information result in any behavior modifications?
2. Typically, genomic testing services group the traits they test for into categories such as (1) recessive disorders, (2)
drug response, (3) risk factors, and (4) non-health related traits. Consider the four traits mentioned in Part II
(Alzheimer's disease, warfarin sensitivity, asparagus metabolite detection, and alcohol flush reaction). In which
category does each trait belong?
3. Would you have liked to know your APOE status regardless of the results? Why or why not?
4. Do you think that Josie should be obligated to tell her family members the results? Why or why not? Would you
feel differently based on different APOE results? Would you feel differently if you were a carrier for a recessive
disease? If you had the allele for Huntington's disease, an autosomal dominant disorder characterized by progressive
neurodegeneration?
Page 10
Expert Solution
![](/static/compass_v2/shared-icons/check-mark.png)
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
This is a popular solution!
Trending now
This is a popular solution!
Step by step
Solved in 2 steps
![Blurred answer](/static/compass_v2/solution-images/blurred-answer.jpg)
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Recommended textbooks for you
![Human Anatomy & Physiology (11th Edition)](https://www.bartleby.com/isbn_cover_images/9780134580999/9780134580999_smallCoverImage.gif)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
![Biology 2e](https://www.bartleby.com/isbn_cover_images/9781947172517/9781947172517_coverImage_Textbooks.gif)
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
![Anatomy & Physiology](https://www.bartleby.com/isbn_cover_images/9781259398629/9781259398629_smallCoverImage.gif)
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
![Human Anatomy & Physiology (11th Edition)](https://www.bartleby.com/isbn_cover_images/9780134580999/9780134580999_smallCoverImage.gif)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
![Biology 2e](https://www.bartleby.com/isbn_cover_images/9781947172517/9781947172517_coverImage_Textbooks.gif)
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
![Anatomy & Physiology](https://www.bartleby.com/isbn_cover_images/9781259398629/9781259398629_smallCoverImage.gif)
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
![Molecular Biology of the Cell (Sixth Edition)](https://www.bartleby.com/isbn_cover_images/9780815344322/9780815344322_smallCoverImage.gif)
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
![Laboratory Manual For Human Anatomy & Physiology](https://www.bartleby.com/isbn_cover_images/9781260159363/9781260159363_smallCoverImage.gif)
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
![Inquiry Into Life (16th Edition)](https://www.bartleby.com/isbn_cover_images/9781260231700/9781260231700_smallCoverImage.gif)
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education