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Place the compounds in the order they will elute from the column when separated using reverse-phase liquid chromatography (RPLC). CH3 CH3 p-xylene napthalene CH3 anisole OH phenol anisole p-xylene Elutes first Elutes last Answer Bank naphthalene phenol

Place the compounds in the order they will elute from the column when separated using reverse-phase liquid chromatography (RPLC). CH3 CH3 p-xylene napthalene CH3 anisole OH phenol anisole p-xylene Elutes first Elutes last Answer Bank naphthalene phenol

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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**Educational Content on Reverse-Phase Liquid Chromatography (RPLC):** In this exercise, you will arrange compounds in the order they elute from a column during reverse-phase liquid chromatography (RPLC). The goal is to understand how different compounds separate based on their polarity. **Compounds to Arrange:** 1. **p-Xylene** - A hydrocarbon with two methyl groups attached to a benzene ring. It is non-polar. 2. **Anisole** - Consists of a methoxy group attached to a benzene ring. It is relatively non-polar. 3. **Naphthalene** - Contains two fused benzene rings. It is non-polar. 4. **Phenol** - A benzene ring with a hydroxyl group. It is polar due to the hydroxyl group. **Instruction:** Use the “Answer Bank” to place these compounds in the column provided. The column is marked with “Elutes first” at the top and “Elutes last” at the bottom. Your task is to arrange them based on their order of elution. **Answer Bank:** - Anisole - Naphthalene - Phenol - p-Xylene **Explanation:** In RPLC, compounds are separated based on their hydrophobic interactions with the stationary phase. Polar compounds elute first, and non-polar compounds elute last. Understanding this order is critical in applications like organic chemistry and biochemistry where separation of compounds is necessary for analysis and synthesis.
Transcribed Image Text:**Educational Content on Reverse-Phase Liquid Chromatography (RPLC):** In this exercise, you will arrange compounds in the order they elute from a column during reverse-phase liquid chromatography (RPLC). The goal is to understand how different compounds separate based on their polarity. **Compounds to Arrange:** 1. **p-Xylene** - A hydrocarbon with two methyl groups attached to a benzene ring. It is non-polar. 2. **Anisole** - Consists of a methoxy group attached to a benzene ring. It is relatively non-polar. 3. **Naphthalene** - Contains two fused benzene rings. It is non-polar. 4. **Phenol** - A benzene ring with a hydroxyl group. It is polar due to the hydroxyl group. **Instruction:** Use the “Answer Bank” to place these compounds in the column provided. The column is marked with “Elutes first” at the top and “Elutes last” at the bottom. Your task is to arrange them based on their order of elution. **Answer Bank:** - Anisole - Naphthalene - Phenol - p-Xylene **Explanation:** In RPLC, compounds are separated based on their hydrophobic interactions with the stationary phase. Polar compounds elute first, and non-polar compounds elute last. Understanding this order is critical in applications like organic chemistry and biochemistry where separation of compounds is necessary for analysis and synthesis.
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