Phosphoric acid is a triprotic acid and the phosphate buffer system is used to buffer cells around 6.9 – 7.4. H3PO4(s) + H2O(1) -> H3O+ (aq) + H₂PO4 (aq) H2PO4(aq)+ H2O(1) -> H3O+ (aq) + HPO4²¯ (aq) HPO4²¯ (aq) + H2O(1) -> H3O+ (aq) + PO4³¯ (aq) Kai= 7.25×10¯³ Ka2= 6.31×10-8 Ka3 = 4.80×10¯13

Curren'S Math For Meds: Dosages & Sol
11th Edition
ISBN:9781305143531
Author:CURREN
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Chapter9: Parenteral Medication Labels And Dosage Calculation
Section: Chapter Questions
Problem 2.2P
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1. Sketch the general shape of the titration curve for the addition of hydroxide to phosphoric acid all the way to phosphate.

2. Given the cellular pH, which chemical species are present in the cell? Label the relevant weak acid and conjugate base

3. For the relevant equilibrium present in the cell, sketch the titration curve. Make sure the following are labeled:

  1. The x and y axes.
  2. The relevant pKa.
  3. The endpoint.
  4. The buffer zone.
  5. The point at which there is a 50/50 mixture of weak acid and conjugate base.
  6. The relative amounts of the weak acid and conjugate base (use the specific chemical species you determined in part 3) along each segment of the titration curve
Phosphoric acid is a triprotic acid and the phosphate buffer system is used to buffer cells around 6.9 – 7.4.
H3PO4(s) + H2O(1) -> H3O+ (aq) + H₂PO4 (aq)
H2PO4(aq)+ H2O(1) -> H3O+ (aq) + HPO4²¯ (aq)
HPO4²¯ (aq) + H2O(1) -> H3O+ (aq) + PO4³¯ (aq)
Kai= 7.25×10¯³
Ka2= 6.31×10-8
Ka3 = 4.80×10¯13
Transcribed Image Text:Phosphoric acid is a triprotic acid and the phosphate buffer system is used to buffer cells around 6.9 – 7.4. H3PO4(s) + H2O(1) -> H3O+ (aq) + H₂PO4 (aq) H2PO4(aq)+ H2O(1) -> H3O+ (aq) + HPO4²¯ (aq) HPO4²¯ (aq) + H2O(1) -> H3O+ (aq) + PO4³¯ (aq) Kai= 7.25×10¯³ Ka2= 6.31×10-8 Ka3 = 4.80×10¯13
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