Penicillins and other β-lactam antibiotics typically develop a resistance to bacteria due to bacterial synthesis of β-lactamase enzymes. Tazobactam, however, is able to inhibit the activity of the β-lactamase by trapping it, thereby preventing resistance from developing. Draw curved arrows to show the movement of electrons in this step of the reaction mechanism.

Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
icon
Related questions
icon
Concept explainers
Question

Penicillins and other β-lactam antibiotics typically develop a resistance to bacteria due to bacterial synthesis of β-lactamase enzymes. Tazobactam, however, is able to inhibit the activity of the β-lactamase by trapping it, thereby preventing resistance from developing. Draw curved arrows to show the movement of electrons in this step of the reaction mechanism.

ö:
:0: :0:
N.
CH3
CH3
N.
N.
N'
N.
N
Énz
Enz
СООН
COOH
Nu
Nu
Transcribed Image Text:ö: :0: :0: N. CH3 CH3 N. N. N' N. N Énz Enz СООН COOH Nu Nu
Enz-Nu
OH
NH
Énz
CH3
CH3
Nu
COOH
HOOC
B-lactamase
Tazobactam
Trapped B-lactamase
Transcribed Image Text:Enz-Nu OH NH Énz CH3 CH3 Nu COOH HOOC B-lactamase Tazobactam Trapped B-lactamase
Expert Solution
steps

Step by step

Solved in 4 steps with 3 images

Blurred answer
Knowledge Booster
Catalysis and Enzymatic Reactions
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Chemistry
Chemistry
Chemistry
ISBN:
9781305957404
Author:
Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:
Cengage Learning
Chemistry
Chemistry
Chemistry
ISBN:
9781259911156
Author:
Raymond Chang Dr., Jason Overby Professor
Publisher:
McGraw-Hill Education
Principles of Instrumental Analysis
Principles of Instrumental Analysis
Chemistry
ISBN:
9781305577213
Author:
Douglas A. Skoog, F. James Holler, Stanley R. Crouch
Publisher:
Cengage Learning
Organic Chemistry
Organic Chemistry
Chemistry
ISBN:
9780078021558
Author:
Janice Gorzynski Smith Dr.
Publisher:
McGraw-Hill Education
Chemistry: Principles and Reactions
Chemistry: Principles and Reactions
Chemistry
ISBN:
9781305079373
Author:
William L. Masterton, Cecile N. Hurley
Publisher:
Cengage Learning
Elementary Principles of Chemical Processes, Bind…
Elementary Principles of Chemical Processes, Bind…
Chemistry
ISBN:
9781118431221
Author:
Richard M. Felder, Ronald W. Rousseau, Lisa G. Bullard
Publisher:
WILEY