Pathways to cell death in ischaemia There are many overlapping and interacting events and pathways involved in ischaemic injury in the brain. Create your own “vision/map” of these pathways and how they interact Diagram - pictures Flowchart A combination You should consider including The initial event Cellular energy failure Excitotoxicity Ca2+ overload Oxidative stress Inflammation Apoptosis & necrosis Reperfusion injury
Pathways to cell death in ischaemia
There are many overlapping and interacting events and pathways involved in ischaemic injury in the brain.
Create your own “vision/map” of these pathways and how they interact
Diagram - pictures Flowchart
A combination
You should consider including
The initial event
Cellular energy failure
Excitotoxicity
Ca2+ overload
Oxidative stress
Inflammation
Apoptosis & necrosis Reperfusion injury
Points for therapeutic intervention
Looking at the diagrams of events in the ischaemic cascade – identify at least 3 points at which you could potentially interact with this cascade with a drug- based therapeutic.
Indicate with what the drug would interact (enzyme, channel, receptor, transporter etc)
And what kind of action you would expect it to have.
Why would you expect this target might be useful in preventing downstream damage for stroke patients?
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