P13.5: The biosynthetic pathway for the antibiotic compound rabelomycin begins with thecondensation of malonyl CoA and acetyl CoA. Predict the product of this reaction, and propose alikely mechanism. (Org. Lett. 2010 12, 2814.)? ?ΘΟmalonyl CoASCOA+COASCH3acetyl CoACO2HSCOA

Step 1: Step 2: Step 3: Step 4:

Answered: P13.5: The biosynthetic pathway for the…

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter21: Carboxylic Acid Derivatives: Nucleophilic Acyl Substitution Reactions

Section21.SE: Something Extra

Problem 41MP

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P13.5: The biosynthetic pathway for the antibiotic compound rabelomycin begins with the condensation of malonyl CoA and acetyl CoA. Predict the product of this reaction, and propose a likely mechanism. (Org. Lett. 2010 12, 2814.) ? ? ΘΟ malonyl CoA SCOA + COAS CH3 acetyl CoA CO2 HSCOA