One of the hallmarks of competitive inhibition is that there is constant competition between the substrate and the inhibitor for binding to the enzyme active site. a) If [inhibitor] >> [substrate], which compound “wins” (i.e., occupies the active site a greater percentage of the time)? b) If [substrate] >> [inhibitor], which compound “wins” (i.e., occupies the active site a greater percentage of the time)?
Enzyme kinetics
In biochemistry, enzymes are proteins that act as biological catalysts. Catalysis is the addition of a catalyst to a chemical reaction to speed up the pace of the reaction. Catalysis can be categorized as either homogeneous or heterogeneous, depending on whether the catalysts are distributed in the same phase as that of the reactants. Enzymes are an essential part of the cell because, without them, many organic processes would slow down and thus will affect the processes that are important for cell survival and sustenance.
Regulation of Enzymes
A substance that acts as a catalyst to regulate the reaction rate in the living organism's metabolic pathways without itself getting altered is an enzyme. Most of the biological reactions and metabolic pathways in the living systems are carried out by enzymes. They are specific for their works and work in particular conditions. It maintains the best possible rate of reaction in the most stable state. The enzymes have distinct properties as they can proceed with the reaction in any direction, their particular binding sites, pH specificity, temperature specificity required in very few amounts.
One of the hallmarks of competitive inhibition is that there is constant competition between
the substrate and the inhibitor for binding to the enzyme active site.
a) If [inhibitor] >> [substrate], which compound “wins” (i.e., occupies the active site a greater
percentage of the time)?
b) If [substrate] >> [inhibitor], which compound “wins” (i.e., occupies the active site a greater
percentage of the time)?
Enzymes are high molecular weight proteins that catalyse biochemical reactions. They contain an active site where the substrate binds to form a short-lived enzyme-substrate complex that soon dissociates into product and free enzyme.
The catalytic activity of an enzyme is a measure of how much product is formed or how much substrate is converted into product per minute by the enzyme.
Enzyme inhibition is when an inhibitor bind to the enzyme at the active site or another site, which results in either decrease in the enzyme's catalytic activity or the enzyme's catalytic activity coming to a complete halt.
Enzyme inhibition can be reversible or irreversible.
Reversible inhibition is when the inhibitor binds reversibly to the enzyme. It can be competitive, un-competitive or noncompetitive.
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