Which of the following is NOT true of a competitive inhibitor? A) Its effects can be overcome by increasing the concentration of substrat B) It competes with substrate for binding to the active site. OC) It irreversibly inhibits the enzyme by chemically modifying a group at the active site. It often resembles the substrate for the enzyme it inhibits.
Inhibitors are biomolecules which binds to enzyme's active site (substrate binding site) or any other site and inhibits its activity. Inhibitors can be irreversible (permanent and binds by covalent bonds) and reversible (temporary and binds by non-covalent interactions). Types of reversible inhibitors - competitive, uncompetitive and non-competitive inhibitors.
Competitive inhibitors binds to substrate binding site - active site and eventually competes with substrate for binding.
Non-competitive inhibitors binds to another binding site instead to active site of enzyme and ultimately does not compete with substrate for binding. it can bind to both free enzyme and enzyme-substrate complex.
uncompetitive inhibitors binds to enzyme-substrate complex only. It binds to another binding site instead to active site of enzyme and ultimately does not compete with substrate for binding.
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