One definition of analytical method limit of quantitation, LOD, in a GLP laboratory is a signal that is 3 times as great as the standard deviation s of a blank or a low-level sample. If m is the slope of the calibration curve: LOD = 3s/m A single quality control (QC) sample was run in replicates of six to produce the following mass spectral peak area signals: 1.7, 1.8, 1.9, 2.1, 2.2, 2.3, 2.7, and 2.3 peak area. The slope of the calibration curve is m = 0.5 peak area/uM. Find the minimum detectable concentration. O 0.3 microMolar O 8.2 microMolar O 1.8 microMolar 04.3 microMolar

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One definition of analytical method limit of quantitation, LOD, in a GLP laboratory is a
signal that is 3 times as great as the standard deviation s of a blank or a low-level
sample. If m is the slope of the calibration curve:
LOD = 3s/m
A single quality control (QC) sample was run in replicates of six to produce the following
mass spectral peak area signals: 1.7, 1.8, 1.9, 2.1, 2.2, 2.3, 2.7, and 2.3 peak area. The
slope of the calibration curve is m = 0.5 peak area/uM. Find the minimum detectable
concentration.
O 0.3 microMolar
O 8.2 microMolar
O 1.8 microMolar
O4.3 microMolar
Transcribed Image Text:One definition of analytical method limit of quantitation, LOD, in a GLP laboratory is a signal that is 3 times as great as the standard deviation s of a blank or a low-level sample. If m is the slope of the calibration curve: LOD = 3s/m A single quality control (QC) sample was run in replicates of six to produce the following mass spectral peak area signals: 1.7, 1.8, 1.9, 2.1, 2.2, 2.3, 2.7, and 2.3 peak area. The slope of the calibration curve is m = 0.5 peak area/uM. Find the minimum detectable concentration. O 0.3 microMolar O 8.2 microMolar O 1.8 microMolar O4.3 microMolar
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