On the trail of carbons. Tissue culture cells were incubated withglutamine labeled with 15NN in the amide group. Subsequently,IMP was isolated and found to contain some 15N.N. Which atomsin IMP were labeled?

IMP is the precursor to both AMP and GMP.

Answered: On the trail of carbons. Tissue culture…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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On the trail of carbons. Tissue culture cells were incubated with glutamine labeled with 15NN in the amide group. Subsequently, IMP was isolated and found to contain some 15N.N. Which atoms in IMP were labeled?