A liquid/liquid extraction is performedto separate the following drug from aurine sample: Ibuprofen.The drug has a pka of 4.43+0.03 andan n-octanol/water partition coefficientof 11.7 at pH 7.4.1. Assume you have a 20nMconcentration of the drug in urine. Youperform a liquid/liquid extraction of20mL of urine with 10 mL of octanol atpH 7.4. What is your percent recovery?2. Would your recovery be higher orlower at pH 2.0?3. Explain what steps you would useto extract the drug by solid phaseextraction.7:55 PM V

The urine formation as, glomerular filtration, tubular reabsorption tubular secretion

Answered: of 4.43±0. partition c

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of 4.43±0. partition c

Fundamentals Of Analytical Chemistry

9th Edition

ISBN:9781285640686

Author:Skoog

Publisher:Skoog

Chapter28: Atomic Spectroscopy

Section: Chapter Questions

Problem 28.13QAP

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Question

A liquid/liquid extraction is performed
to separate the following drug from a
urine sample: Ibuprofen.
The drug has a pka of 4.43+0.03 and
an n-octanol/water partition coefficient
of 11.7 at pH 7.4.
1. Assume you have a 20nM
concentration of the drug in urine. You
perform a liquid/liquid extraction of
20mL of urine with 10 mL of octanol at
pH 7.4. What is your percent recovery?
2. Would your recovery be higher or
lower at pH 2.0?
3. Explain what steps you would use
to extract the drug by solid phase
extraction.
7:55 PM V

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