Objective:  Apply knowledge of skeletal, muscular and nervous physiology to clearly, accurately and logically analyze a case study.  Scenario Brandon Wilkes is a star quarterback and is looking forward to next week’s game when scouts from his top pick school will be attending.  Brandon confided to the coach that he had been depressed recently and last week began feeling weaker in the weight room during training sessions.  The coach explained that he was working hard and he could rest after the season was over.  One minute three seconds before half time, Brandon ran out of the pocket when he couldn’t find anyone open, made it 15 yards before a defender took him down at the knee.  At the hospital, X-rays confirmed a spiral fracture of the tibia and fibula.  As the radiologist examined the pictures, she noticed excessive bone loss in the shaft of the tibia.  Bloodwork came back from the lab and revealed a blood calcium level of 12.5 mg/dL.  The normal range is 8.5-10.5 mg/dL.  The lab results came in the levels of parathyroid hormone in Brandon’s blood was much higher than the normal levels. Diagnose this patient. Why would muscle weakness be a symptom of this diagnosis?  Explain using you knowledge of the action potential along the motor neuron.  Would the action potentials be faster or slower?  Would they be as frequent?  What are the implications on muscle contraction if the frequency is altered? Part IV.  A drug study.  Cocaine is a stimulant drug and acts to block the dopamine reuptake pumps located at the terminal knobs of pre-synaptic neurons.  Discuss how this inhibition could lead to the stimulatory effects on the post-synaptic neuron.

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Objective:  Apply knowledge of skeletal, muscular and nervous physiology to clearly, accurately and logically analyze a case study. 

Scenario

Brandon Wilkes is a star quarterback and is looking forward to next week’s game when scouts from his top pick school will be attending.  Brandon confided to the coach that he had been depressed recently and last week began feeling weaker in the weight room during training sessions.  The coach explained that he was working hard and he could rest after the season was over. 

One minute three seconds before half time, Brandon ran out of the pocket when he couldn’t find anyone open, made it 15 yards before a defender took him down at the knee.  At the hospital, X-rays confirmed a spiral fracture of the tibia and fibula.  As the radiologist examined the pictures, she noticed excessive bone loss in the shaft of the tibia. 

Bloodwork came back from the lab and revealed a blood calcium level of 12.5 mg/dL.  The normal range is 8.5-10.5 mg/dL. 

  1. The lab results came in the levels of parathyroid hormone in Brandon’s blood was much higher than the normal levels.
  2. Diagnose this patient.
  3. Why would muscle weakness be a symptom of this diagnosis?  Explain using you knowledge of the action potential along the motor neuron.  Would the action potentials be faster or slower?  Would they be as frequent?  What are the implications on muscle contraction if the frequency is altered?

Part IV.  A drug study.  Cocaine is a stimulant drug and acts to block the dopamine reuptake pumps located at the terminal knobs of pre-synaptic neurons.  Discuss how this inhibition could lead to the stimulatory effects on the post-synaptic neuron.

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