Nicotine patches are often used to help smokers quit. Does giving medicine to fight depression also help? A randomized double-blind experiment assigned 244 smokers to receive nicotine patches and another 245 to receive both a patch and the antidepressant drug bupropion. After a year, 40 subjects in the nicotine patch group had abstained from smoking, as had 87 in the patch-plus-drug group. (a) Construct and interpret a 99% confidence interval for the difference in the proportion of smokers who abstain when using buproprion and a nicotine patch and the proportion who abstain when using only a patch. (b) Based only on this interval, do you think that the difference in proportion of abstaining smokers is significant? Justify your answer.

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Nicotine patches are often used to help smokers quit. Does giving medicine to fight depression
also help? A randomized double-blind experiment assigned 244 smokers to receive nicotine
patches and another 245 to receive both a patch and the antidepressant drug bupropion. After a
year, 40 subjects in the nicotine patch group had abstained from smoking, as had 87 in the
patch-plus-drug group.
(a) Construct and interpret a 99% confidence interval for the difference in the proportion of
smokers who abstain when using buproprion and a nicotine patch and the proportion who
abstain when using only a patch.
(b) Based only on this interval, do you think that the difference in proportion of abstaining
smokers is significant? Justify your answer.

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