N-acetylphenylalaninamide2. (a)is a substrate of a-chymotrypsin. Draw the structuralformula of this molecule, indicate which bond is cleaved in the hydrolytic reaction, and explain from itsstructure why it is a specific substrate of a-chymotrypsin. What influence does the acetyl group haveon the reaction?(b)The table on the right lists initial velocitydata for hydrolysis of N-acetylphenylalaninamide catal-yzed by a-chymotrypsin. From the data calculate thevalue of KM by a graphical method using a rectangularhyperbolic function to relate velocity to substrate con-centration and compare the results to the valueobtained by a linear least-squares fit of the data in theform of a double-reciprocal plot.Substrateconc. (mm)10.516.120.035.093.4Vo(mmole/min)3.33 x 10-²4.55 x 10-²5.56 x 10-²7.15 x 10-²10.0 x 10-²

Chymotrypsin is a Serine protease that hydrolyses peptides bonds at the Carboxy terminus of Aromatic…

Answered: N-acetylphenylalaninamide 2. (a) is a…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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22) A) Write the structure for a generic triacvlglyceride at pH 7.4. B) Show the mechanism of a lipase including the catalytic triad and the oxyanion hole up to the tetrahedral intermediate of the cleavage of the acyl-alcohol bond. C) What is the purpose of the þxyanion hole? D) How does the catalytic triad function to lower the pKa of serine. coo coo H,N-C-H H,N-C-H CH, CH2 он Serine (S) (Ser) HN Histidine (H) (His) coo co H,N-C-H H,N-C-H H CH, Glycine (G) (Gly) coo Aspartate [D] (Asp)
Draw structural formulas for the alkoxide ion and the alkyl(aryl)bromide that may be used in a Williamson synthesis of the ether shown. CH3CH2CH2CH2-0-CH2CH2CH2CH3 • You do not have to consider stereochemistry. • Do not include counter-ions, e.g., Na*, I, in your answer. • Draw one structure per sketcher. Add additional sketchers using the drop-down menu in the bottom right corner. O Separate structures with + signs from the drop-down menu.
3L6
2.7 Now that you have figured out the reaction mechanism, let's explore the action mechanism of the following drug. Notice that this molecule is composed of two chloroethylamine groups and therefore can react with two different nucleophiles. Complete the following reaction mechanism. R-N Cl CL + R'-NH₂ R"-NH₂ The above reaction is responsible for the activity of the drug. Because of its ability to react with two nucleophiles, the drug can create a bridge between two biologically active molecules and disrupt their activity. This process is known as 'cross-linking'. For example, it can react with two DNA strands and prevent their separation during replication. This will cause cytotoxicity and cell death. 2.8 Draw a scheme/cartoon to represent the general idea of chemical cross-linking described above.
3. (а) (coenzyme A), NAD+ (oxidized nicotinamide adenine dinucleotide), FAD (oxidized flavin adenine dinu- cleotide), and a five-membered ring for oxidized lipoamide, and using structural formulas outline the reactions for the oxidative decarboxylation of a-ketoglutarate catalyzed by the aKG dehydrogenase complex. Name the 3 enzymes catalyzing the reactions underlying the conversion of a-ketoglutarate. Using the following abbreviations for cofactors: TPP (thiamine pyrophosphate), COASH
What is this product?
Balance the reactions. A hint is provided to help you decide if the reaction will proceed as written, ie from left to right. Do not leave any fractions. 1. a) Balance Al₂O3 → Al + 0₂ b) What type of reaction is this? c) Is this a redox rx, yes / no ? d) The reaction will go from left to right, yes / no ? (hint: O₂ is very reactive) 2. a) Balance HNO3 + AI → b) What type of reaction is this? c) Is this a redox rx, yes / no ? d) The reaction will go from left to right, yes / no ? (hint: aluminum is a reactive metal, and a gas escapes) C7H14 + 0₂ 3. a) Balance, leave no fractions b) What type of reaction is this? c) Is this a redox rx, yes / no ? d) The reaction will go from left to right, yes / no ? (hint: O₂ is very reactive) H2(g) + AI(NO3)3 → CO₂ + H₂O
please help me identify these huhu thank you
23
None
In the structure of vancomycin, what moiety contributes to its solubility in polar medium?
None

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