Multistep synthesis of Lidocaine Lab 1) How many grams of starting material do you need? It is given in moles below but how many grams? 2) How to calculate theoretical yield? Part One Method A. Preparation of alpha-Chloro-2,6-dimethylacetanilideCombine 0.033 mol of 2,6-dimethylaniline with 25 mL of glacial acetic acid (or ethyl acetateor THF) and 0.033 mol of alpha-chloroacetyl chloride, in that order, in an appropriately sized Erlenmeyer flask. With the aid of a hot water bath, warm the solution to 40-50°C, remove the flask from the bath, and add a solution of 5 g of sodium acetate trihydrate dissolved in 100 mL of water.

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Multistep synthesis of Lidocaine Lab

1) How many grams of starting material do you need? It is given in moles below but how many grams?

2) How to calculate theoretical yield?

Part One Method

A. Preparation of alpha-Chloro-2,6-dimethylacetanilideCombine 0.033 mol of 2,6-dimethylaniline with 25 mL of glacial acetic acid (or ethyl acetateor THF) and 0.033 mol of alpha-chloroacetyl chloride, in that order, in an appropriately sized Erlenmeyer flask. With the aid of a hot water bath, warm the solution to 40-50°C, remove the flask from the bath, and add a solution of 5 g of sodium acetate trihydrate dissolved in 100 mL of water. 

NH2
CI
(CH3CH2)2NH
CH3CO2H, CH3COONA
PҺCH3, 110 С
or CH3COOEt or THF
2,6-dimethylaniline
Lidocaine
IZ
Transcribed Image Text:NH2 CI (CH3CH2)2NH CH3CO2H, CH3COONA PҺCH3, 110 С or CH3COOEt or THF 2,6-dimethylaniline Lidocaine IZ
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