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MnO2 HCI NaCN C В H20 HCI (Give all products (2 pts each)

MnO2 HCI NaCN C В H20 HCI (Give all products (2 pts each)

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Give the major organic product(s) for each of the following reactions. Write NR if a reaction will not occur.

### Reaction 1: **Starting Material:** Cyclohexanol **Reaction Sequence:** 1. **Reagent:** MnO<sub>2</sub> **Product A:** Formation of cyclohexanone. 2. **Reagent:** NaCN, HCl **Product B:** Conversion to a cyanohydrin via nucleophilic addition. 3. **Reagent:** HCl, H<sub>2</sub>O **Product C:** Hydrolysis of the cyanohydrin to give α-hydroxy acid. **Instructions:** Give all products for 2 points each. --- ### Reaction 2: **Starting Material:** 1-Butyne **Reaction Sequence:** 1. **Reagents:** - Step 1: BH<sub>3</sub>/THF - Step 2: H<sub>2</sub>O<sub>2</sub>, OH<sup>-</sup>, H<sub>2</sub>O **Product A:** Hydroboration-oxidation to convert the alkyne into an alcohol. 2. **Reagents:** - Step 1: CH<sub>3</sub>MgBr - Step 2: H<sub>2</sub>O or H<sub>3</sub>O<sup>+</sup> **Product B:** Reaction with Grignard reagent leading to a secondary alcohol. **Instructions:** Give all 2 products for 2 points each. --- ### Reaction 3: **Starting Material:** Benzene **Reaction Sequence:** 1. **Reagent:** AlCl<sub>3</sub> **Intermediate/Product A:** Formation of an acylated benzene. 2. **Reagent:** Ph<sub>3</sub>P=CHCH<sub>3</sub> **Product B:** Wittig reaction to convert the ketone into an alkene. **Instructions:** Give both products. --- Diagrams for each reaction illustrate the structures and transformations involved. The first diagram shows the transformation of alcohol to an acid via oxidation and nucleophilic addition. The second outlines hydroboration-oxidation followed by a Grignard reaction. The third illustrates Friedel-Crafts acylation leading to a Wittig modification.
Transcribed Image Text:### Reaction 1: **Starting Material:** Cyclohexanol **Reaction Sequence:** 1. **Reagent:** MnO<sub>2</sub> **Product A:** Formation of cyclohexanone. 2. **Reagent:** NaCN, HCl **Product B:** Conversion to a cyanohydrin via nucleophilic addition. 3. **Reagent:** HCl, H<sub>2</sub>O **Product C:** Hydrolysis of the cyanohydrin to give α-hydroxy acid. **Instructions:** Give all products for 2 points each. --- ### Reaction 2: **Starting Material:** 1-Butyne **Reaction Sequence:** 1. **Reagents:** - Step 1: BH<sub>3</sub>/THF - Step 2: H<sub>2</sub>O<sub>2</sub>, OH<sup>-</sup>, H<sub>2</sub>O **Product A:** Hydroboration-oxidation to convert the alkyne into an alcohol. 2. **Reagents:** - Step 1: CH<sub>3</sub>MgBr - Step 2: H<sub>2</sub>O or H<sub>3</sub>O<sup>+</sup> **Product B:** Reaction with Grignard reagent leading to a secondary alcohol. **Instructions:** Give all 2 products for 2 points each. --- ### Reaction 3: **Starting Material:** Benzene **Reaction Sequence:** 1. **Reagent:** AlCl<sub>3</sub> **Intermediate/Product A:** Formation of an acylated benzene. 2. **Reagent:** Ph<sub>3</sub>P=CHCH<sub>3</sub> **Product B:** Wittig reaction to convert the ketone into an alkene. **Instructions:** Give both products. --- Diagrams for each reaction illustrate the structures and transformations involved. The first diagram shows the transformation of alcohol to an acid via oxidation and nucleophilic addition. The second outlines hydroboration-oxidation followed by a Grignard reaction. The third illustrates Friedel-Crafts acylation leading to a Wittig modification.
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