16) Select the major product of the following series of reactions. a) H===H b) 1) NaNH, 2) CH,CH₂CH₂Br 3) 9-BBN 4) H₂O₂(aq), NaOH(aq) OH c) ? OH
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
Solve question 16)
![**Question 16: Reaction Series Product Selection**
**Description:** The task is to determine the major product from a sequence of organic reactions.
**Reaction Sequence:**
1. **Reactant:**
- Alkyne (H-C≡C-H)
2. **Reagents and Conditions:**
- Step 1: Sodium amide (NaNH₂)
- Step 2: Propyl bromide (CH₃CH₂CH₂Br)
- Step 3: 9-Borabicyclo[3.3.1]nonane (9-BBN)
- Step 4: Aqueous hydrogen peroxide and sodium hydroxide (H₂O₂(aq), NaOH(aq))
**Options for Major Product:**
- a) An aldehyde with a three-carbon chain attached to a double-bonded oxygen
- b) A carboxylic acid with a three-carbon chain attached to a double-bonded oxygen and an OH group
- c) A ketone with a four-carbon chain
- d) An alcohol with a four-carbon chain
**Explanation:**
The original alkyne undergoes a series of reactions involving substitution, hydroboration, and oxidation to yield the end product. Based on the reagents and transformations involved (e.g., hydroboration-oxidation), students should analyze the mechanism and predict the correct organic product from the options provided.
This example highlights the transformations of a terminal alkyne into a functionalized four-carbon product through organometallic and oxidative processes.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fcf76ebb0-a1fb-4e27-be44-e5f7107968b4%2F773c9d55-5d8f-4c57-870d-5960cadab80a%2Fjecwsim_processed.jpeg&w=3840&q=75)
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