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MetaNeuron Lesson 4 1. Action Potential Threshold. Vary the amplitude of "Stimulus 1". What effect does this have on the cell response (Figure 7)? What is the threshold stimulus amplitude (in uA) for initiating an action potential? The threshold stimulus is best measured by adjusting the stimulus amplitude in 0.1 µA increments until it is just large enough to initiate an action potential. Click on the "Stimulus 1 Amplitude" gray button and move the mouse while holding down the ctrl key. 2. Action Potentials and the Na+ equilibrium potential. Set "Stimulus 1 Amplitude" to 150 µA. The stimulus will evoke an action potential. Vary the "Na+ equilibrium potential". What effect does this have on the action potential? Why? 3. Action potentials and gK max. Using a "Stimulus 1 Amplitude" of 150 µA and a "Na+ equilibrium potential" of 50 mV, vary "gK max". What effect does this have on the time to action potential initiation and the width of the action potential? Why?

MetaNeuron Lesson 4 1. Action Potential Threshold. Vary the amplitude of "Stimulus 1". What effect does this have on the cell response (Figure 7)? What is the threshold stimulus amplitude (in uA) for initiating an action potential? The threshold stimulus is best measured by adjusting the stimulus amplitude in 0.1 µA increments until it is just large enough to initiate an action potential. Click on the "Stimulus 1 Amplitude" gray button and move the mouse while holding down the ctrl key. 2. Action Potentials and the Na+ equilibrium potential. Set "Stimulus 1 Amplitude" to 150 µA. The stimulus will evoke an action potential. Vary the "Na+ equilibrium potential". What effect does this have on the action potential? Why? 3. Action potentials and gK max. Using a "Stimulus 1 Amplitude" of 150 µA and a "Na+ equilibrium potential" of 50 mV, vary "gK max". What effect does this have on the time to action potential initiation and the width of the action potential? Why?

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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MetaNeuron Lesson 4 1. Action Potential Threshold. Vary the amplitude of "Stimulus 1". What effect does this have on the cell response (Figure 7)? What is the threshold stimulus amplitude (in uA) for initiating an action potential? The threshold stimulus is best measured by adjusting the stimulus amplitude in 0.1 µA increments until it is just large enough to initiate an action potential. Click on the "Stimulus 1 Amplitude" gray button and move the mouse while holding down the ctrl key. 2. Action Potentials and the Na+ equilibrium potential. Set "Stimulus 1 Amplitude" to 150 μA. The stimulus will evoke an action potential. Vary the "Na+ equilibrium potential". What effect does this have on the action potential? Why? 3. Action potentials and gK max. Using a "Stimulus 1 Amplitude" of 150 μA and a "Na+ equilibrium potential" of 50 mV, vary "gK max". What effect does this have on the time to action potential initiation and the width of the action potential? Why? 4. Na+ channels and Action Potential Initiation. Action potentials are often initiated at the axon hillock, where the axon leaves the cell body. The axon hillock has a high density of Na+ channels, which lowers the threshold for initiating an action potential. MetaNeuron can be used to measure the effect of Na+ channel density on the threshold of action potential generation. Vary "gNa max" from 200 to 380 mS/cm2 in 20 mS/cm2 steps. (Na+ channel density is proportional to gNa max.) For each "gNa max" value, determine the threshold stimulus amplitude (in μA) for initiating an action potential. Plot the threshold current as a function of gNa max. Why does the action potential threshold vary as Na+ channel density is changed?
Transcribed Image Text:MetaNeuron Lesson 4 1. Action Potential Threshold. Vary the amplitude of "Stimulus 1". What effect does this have on the cell response (Figure 7)? What is the threshold stimulus amplitude (in uA) for initiating an action potential? The threshold stimulus is best measured by adjusting the stimulus amplitude in 0.1 µA increments until it is just large enough to initiate an action potential. Click on the "Stimulus 1 Amplitude" gray button and move the mouse while holding down the ctrl key. 2. Action Potentials and the Na+ equilibrium potential. Set "Stimulus 1 Amplitude" to 150 μA. The stimulus will evoke an action potential. Vary the "Na+ equilibrium potential". What effect does this have on the action potential? Why? 3. Action potentials and gK max. Using a "Stimulus 1 Amplitude" of 150 μA and a "Na+ equilibrium potential" of 50 mV, vary "gK max". What effect does this have on the time to action potential initiation and the width of the action potential? Why? 4. Na+ channels and Action Potential Initiation. Action potentials are often initiated at the axon hillock, where the axon leaves the cell body. The axon hillock has a high density of Na+ channels, which lowers the threshold for initiating an action potential. MetaNeuron can be used to measure the effect of Na+ channel density on the threshold of action potential generation. Vary "gNa max" from 200 to 380 mS/cm2 in 20 mS/cm2 steps. (Na+ channel density is proportional to gNa max.) For each "gNa max" value, determine the threshold stimulus amplitude (in μA) for initiating an action potential. Plot the threshold current as a function of gNa max. Why does the action potential threshold vary as Na+ channel density is changed?
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