Looking at the phylogeny below which shows the relationships between the original SARS-CoV virus and the one we are currently facing, SARS-CoV-2. What is the evidence (in the figure that SARS-CoV-2 did not arise from SARS-CoV in humans?

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1. These viruses have likely been around for a very long time. Why are they suddenly evolving to infect human hosts? 2. Looking at the phylogeny below which shows the relationships between the original SARS-CoV virus and the one we are currently facing, SARS-CoV-2. What is the evidence (in the figure that SARS-CoV-2 did not arise from SARS-CoV in humans?

3. What is the evidence  (shown in the figure) that the likely origin of CoV-2 is a bat and not a pangolin?

 

 

100
Sarbecovirus
Hibecovirus
Nobecovirus
0.05
Merbecovirus
100 Embecovirus
100
100
100
100
SARS-CoV-
related
lineage
75
100
100
100
100
88
SARS-CoV-2-
related
lineage
100
SARS-CoV GZ02
100 SARS-CoV SZ3
-SARS-CoV Tor2
99 100 SARS-CoV BJ01
84
100 100
100
91
100
Bat SARSr-CoV Rs4231
Bat SARSr-CoV SHC014
Bat SARS-CoV WIV1
Bat SARSr-CoV YN2018C
Bat SARSr-CoV Rp3
Bat SARSr-CoV HKU3-1
100
Bat SARSr-CoV BM48-31
- Pangolin coronavirus Guangxi
Bat coronavirus ZXC21
Bat coronavirus ZC45
- Pangolin coronavirus Guangdong
Bat coronavirus RmYN02
Bat coronavirus RaTG13
SARS-CoV-2 China/Shenzhen/SZTH002/202001
SARS-CoV-2 USA/CA1/202001
SARS-CoV-2 Singapore/14Clin/202002
SARS-CoV-2 Japan/DP0346/202002
SARS-CoV-2 Australia/VIC04/202003
SARS-CoV-2 Germany/NRW06/202002
SARS-CoV-2 China/Wuhan/WIV04/201912
SARS-CoV-2 Vietnam/CM295/202003
SARS-CoV-2 Italy/CDG1/202002
85 SARS-CoV-2 USA/NYUMC8/202003
Bat Hp-betacoronavirus Zhejiang2013
Rousettus bat coronavirus HKU9
Rousettus bat coronavirus GCCDC1
Pipistrellus bat coronavirus HKUS
Tylonycteris bat coronavirus HKU4
MERS-CoV
Human coronavirus HKU1
Murine hepatitis virus
Human coronavirus OC43
Transcribed Image Text:100 Sarbecovirus Hibecovirus Nobecovirus 0.05 Merbecovirus 100 Embecovirus 100 100 100 100 SARS-CoV- related lineage 75 100 100 100 100 88 SARS-CoV-2- related lineage 100 SARS-CoV GZ02 100 SARS-CoV SZ3 -SARS-CoV Tor2 99 100 SARS-CoV BJ01 84 100 100 100 91 100 Bat SARSr-CoV Rs4231 Bat SARSr-CoV SHC014 Bat SARS-CoV WIV1 Bat SARSr-CoV YN2018C Bat SARSr-CoV Rp3 Bat SARSr-CoV HKU3-1 100 Bat SARSr-CoV BM48-31 - Pangolin coronavirus Guangxi Bat coronavirus ZXC21 Bat coronavirus ZC45 - Pangolin coronavirus Guangdong Bat coronavirus RmYN02 Bat coronavirus RaTG13 SARS-CoV-2 China/Shenzhen/SZTH002/202001 SARS-CoV-2 USA/CA1/202001 SARS-CoV-2 Singapore/14Clin/202002 SARS-CoV-2 Japan/DP0346/202002 SARS-CoV-2 Australia/VIC04/202003 SARS-CoV-2 Germany/NRW06/202002 SARS-CoV-2 China/Wuhan/WIV04/201912 SARS-CoV-2 Vietnam/CM295/202003 SARS-CoV-2 Italy/CDG1/202002 85 SARS-CoV-2 USA/NYUMC8/202003 Bat Hp-betacoronavirus Zhejiang2013 Rousettus bat coronavirus HKU9 Rousettus bat coronavirus GCCDC1 Pipistrellus bat coronavirus HKUS Tylonycteris bat coronavirus HKU4 MERS-CoV Human coronavirus HKU1 Murine hepatitis virus Human coronavirus OC43
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