Lipidomics has identified thousands of cellular lipids. LIPID MAPS is an online database containing over 40,000 unique lipid structures, as well as information on the chemical and physical properties of each lipid. One important parameter when working with lipids is logP, where P is the octanol:water partition coefficient, an indicator of lipophilicity. Look up cholesterol, sphingosine, linoleic acid, and stearic acid in LIPID MAPS and use the reported log P values to place them in order of decreasing solubility in octanol.
Lipidomics has identified thousands of cellular lipids. LIPID MAPS is an online database containing over 40,000 unique lipid structures, as well as information on the chemical and physical properties of each lipid. One important parameter when working with lipids is logP, where P is the octanol:water partition coefficient, an indicator of lipophilicity. Look up cholesterol, sphingosine, linoleic acid, and stearic acid in LIPID MAPS and use the reported log P values to place them in order of decreasing solubility in octanol.
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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![Lipidomics has identified thousands of cellular lipids. LIPID MAPS is an online database containing over 40,000 unique lipid
structures, as well as information on the chemical and physical properties of each lipid. One important parameter when working
with lipids is logP, where P is the octanol:water partition coefficient, an indicator of lipophilicity.
Look up cholesterol, sphingosine, linoleic acid, and stearic acid in LIPID MAPS and use the reported log P values to place them
in order of decreasing solubility in octanol.
Most soluble in octanol
stearic acid
linoleic acid
cholesterol
sphingosine
Least soluble in octanol](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F7f8e1c65-6d3c-436a-b1af-c27aeef6edb7%2Fc4076f7f-a481-4de6-8693-76e10952c8e4%2Ftbobp3p_processed.jpeg&w=3840&q=75)
Transcribed Image Text:Lipidomics has identified thousands of cellular lipids. LIPID MAPS is an online database containing over 40,000 unique lipid
structures, as well as information on the chemical and physical properties of each lipid. One important parameter when working
with lipids is logP, where P is the octanol:water partition coefficient, an indicator of lipophilicity.
Look up cholesterol, sphingosine, linoleic acid, and stearic acid in LIPID MAPS and use the reported log P values to place them
in order of decreasing solubility in octanol.
Most soluble in octanol
stearic acid
linoleic acid
cholesterol
sphingosine
Least soluble in octanol
![Log P values are often studied by pharmacologists when developing new drugs.
Select the statements that describe why knowing a drug's log P value would be informative.
Log P determines a drug's binding affinity for receptors on the cell membrane.
Log P determines the likelihood that a drug will be absorbed by fats and fatty tissues.
Log P determines the ability of a drug to be transported through aqueous compartments of the body.
Log P determines a drug's stability at higher temperatures.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F7f8e1c65-6d3c-436a-b1af-c27aeef6edb7%2Fc4076f7f-a481-4de6-8693-76e10952c8e4%2F6cyb9z_processed.jpeg&w=3840&q=75)
Transcribed Image Text:Log P values are often studied by pharmacologists when developing new drugs.
Select the statements that describe why knowing a drug's log P value would be informative.
Log P determines a drug's binding affinity for receptors on the cell membrane.
Log P determines the likelihood that a drug will be absorbed by fats and fatty tissues.
Log P determines the ability of a drug to be transported through aqueous compartments of the body.
Log P determines a drug's stability at higher temperatures.
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