Lactate dehydrogenase (LDH) plays an essential role in an exercising muscle, especially when the level of excursion surpasses the ability of circulatory systems abilityto supply adequate oxygen. What is the main reason LDH is so important to the muscle under these conditions?It produces one mole of ATP via substrate level phosphorylation.It resupplies NAD+ to glyceraldehyde 3-phosphate dehydrogenase.It decreases pH thus decreasing the dissociation rate of oxygen from hemoglobinIt produces NADH for energy while converting pyruvate into lactate.It removes excess lactic acid from the muscle to create pyruvate.Next

During cellular respiration, respiratory substrates like glucose may undergo complete or…

Answered: Lactate dehydrogenase (LDH) plays an…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Lactate dehydrogenase is one of the many enzymes that require NADH as coenzyme. It catalyzes the conversion of pyruvate to lactate:Draw the mechanism of this reaction (show electron-pushing arrows). (Hint: This is a common reaction throughout metabolism; the mechanism is similar to that catalyzed by other dehydrogenases that use NADH, such as alcohol dehydrogenase.)
Which of the following Krebs cycle enzymes generates a molecule of FADH2 from FAD? a-ketoglutarate dehydrogenase pyruvate dehydrogenase isocitrate dehydrogenase malate dehydrogenase succinate dehydrogenase
What type of regulation would be expected when anaerobic metabolism is occurring in the muscle? Select all that apply. 1. Activation of pyruvate dehydrogenase kinase 2. Increased levels of calcium to activate pyruvate dehydrogenase phosphatase 3. Phosphorylation of pyruvate dehydrogenase 4. Inhibition of pyruvate dehydrogenase complex 5. Increased levels of NADH to activate citrate synthase 6. Increased levels of NADH to inhibit alpha-ketogluterate dehydrogenase complex 7. Increased levels of acetyl CoA to activate pyruvate carboxylase for gluconeogenesis
What type of regulation would be expected when anaerobic metabolism is occurring in the muscle? Select all that apply. O Activation of pyruvate dehydrogenase kinase O Increased levels of calcium to activate pyruvate dehydrogenase phosphatase O Phosphorylation of pyruvate dehydrogenase O Inhibition of pyruvate dehydrogenase complex O Increased levels of NADH to activate citrate synthase O Increased levels of NADH to inhibit alpha-ketogluterate dehydrogenase complex O Increased levels of acetyl CoA to activate pyruvate carboxylase for gluconeogenesis
The glycolytic enzymes hexokinase and glucokinase (in human liver cells) catalyze the conversion of: 1,3-bisphosphoglycerate into 3-phosphoglycerate (producing ATP) glyceraldehyde-3-phosphate into 1,3-bisphosphoglycerate (producing NADH) phosphoenolpyruvate into pyruvate (producing ATP) fructose-6-phosphate into fructose-1,6-bisphosphate (consuming ATP) glucose into glucose-6-phosphate (consuming ATP) Which of the following glycolytic enzymes must consume ATP during phosphorylation of its preferred substrate molecule? phosphoglycerate mutase succinate dehydrogenase phosphoglycerate kinase phosphofructokinase pyruvate kinase
Pyruvate dehydrogenase deficiency is a fatal disease usually diagnosed in children. Symptoms include severe neurological damage. Elevated blood levels of lactate, pyruvate, and alanine are also seen. Explain how the deficiency of pyruvate dehydrogenase causes these elevated values.
Which of the following conditions is most likely to force a muscle cell to metabolize glucose anaerobically(fermentation) under normal oxygenation ? - Glyceraldehyde-3-phosphate dehydrogenase deficiency - Lactate dehydrogenase deficiency -Pyruvate kinase deficiency -Aldolase deficiency - Cytososic Glycerol-3-phosphate dehydrogenase deficiency
Which of the following catalyzes a step that does NOT produce CO2? Group of answer choices alpha-ketoglutarate dehydrogenase complex malate dehydrogenase pyruvate dehydrogenase complex isocitrate dehydrogenase Citrate synthase is regulated by... Group of answer choices Concentrations of substrate and products Fructose-2,6-Bisphosphate Covalent modification Allosteric regulation by the levels of NADDH
Lactate dehydrogenase is exist as M (muscle type) lactate dehydrogenase and H (heart type) lactate dehydrogenase. What is the difference between the two isozymes and how they are related to the functions of the muscles and the heart?
Once formed, what are the three possible fates of pyruvate and under what conditions do they occur? Match the appropriate pairs. Clear All pyruvate forms lactate pyruvate forms ethanol pyruvate forms acetyl-CoA under anaerobic conditions in animals under aerobic conditions under anaerobic conditions in yeast and other microorganisms
The heart cannot convert lactate back to glucose, as the liver does, but instead uses it as a fuel. What is the ATP yield from the complete catabolism of one mole of lactate?
which statements are False

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