Answered: Lactase is an enzyme that is…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Question

Lactase is an enzyme that is responsible for hydrolyzing the covalent bond that holds galactose and glucose together in the disaccharide lactose. Deficiencies in the lactase enzyme, lead to lactose intolerance in humans. Using a well labelled graph and a few sentences, explain why lactase is not folded to create an active site that is complimentary to the lactose substrate.

Expert Solution

Step 1

Lactase is enzyme which break down the substrate lactose into glucose and galactose by hydrolyzing covalent bond.
Lactose is disaccharide made up of glucose and galactose. $β$ 1 $\to$ 4 bond is present in between the glucose and galactose.
Lactase play important role in digestion of whole milk. Deficiency of lactase leads to lactose intolerance in human i.e., milk sugar lactose cannot digest completely.
Once lactose is broken down into simple sugar. Bloodstream absorbs those simple sugar.
- - - Lactose