Kindly refer to the image and answer the question 5. Cite a metabolic pathway where active protein kinase is needed and explain its mechanism of action

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Kindly refer to the image and answer the question

5. Cite a metabolic pathway where active protein kinase is needed
 and explain its mechanism of action

1 Unoccupied receptor does
not interact with G, protein.
Extra-
collular
space
-Hormone or neuro-
transmitter
Cell
membrane
Gs protein
with bound GDP
Synaptic signaling
Receptor
Target
cell
Inactive adenylyl
Cytosol
GOP
cyclase
Nerve
cell
Occupied receptor changes
2 shape and interacts with a
subunit of G, protein. G, protein
releases GDP and binds GTP.
Neurotransmitter
Endocrine signaling
Hormone
Inactive
adenylyl
cyclase
GTP
Target
cell
GDP
a Subunit of G, protein
3 dissociates from By and
Blood vessel
activates adenylyl cyclase.
Active
adenylyl
cyclase
Direct contact
АТР
Gap
junction
GTP
CAMP + PP
When hormone is no longer
4 present, the receptor reverts
to resting state. GTP on the
a subunít is hydrolyzed to GDP,
a rejoins By, and adenylyl
cyclase is deactivated.
Signaling
cell
Target
cells
Inactive
adenylyl
cyclase
Transcribed Image Text:1 Unoccupied receptor does not interact with G, protein. Extra- collular space -Hormone or neuro- transmitter Cell membrane Gs protein with bound GDP Synaptic signaling Receptor Target cell Inactive adenylyl Cytosol GOP cyclase Nerve cell Occupied receptor changes 2 shape and interacts with a subunit of G, protein. G, protein releases GDP and binds GTP. Neurotransmitter Endocrine signaling Hormone Inactive adenylyl cyclase GTP Target cell GDP a Subunit of G, protein 3 dissociates from By and Blood vessel activates adenylyl cyclase. Active adenylyl cyclase Direct contact АТР Gap junction GTP CAMP + PP When hormone is no longer 4 present, the receptor reverts to resting state. GTP on the a subunít is hydrolyzed to GDP, a rejoins By, and adenylyl cyclase is deactivated. Signaling cell Target cells Inactive adenylyl cyclase
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