Short Answer 2. You are studying the role of Kinase A and CDKI in neuroblastoma, a type of cancer. In neuroblastoma tumors, mutations are found in genes for both Kinase A and CD inhibit the normal function of CDKI, as diagrammed below. Wild type Kinase A activates mitosis Wild type CDKI inactivates mitosis Wild type Kinase A can inactivate CDKI H- Inhibits CDKI Kinase A Mitosis G2 G1 S-phase A) Would you expect these mutations in CDKI that lead to cancer to be dominant or recessive at tthe cellular level? Explain your thinking.
Short Answer 2. You are studying the role of Kinase A and CDKI in neuroblastoma, a type of cancer. In neuroblastoma tumors, mutations are found in genes for both Kinase A and CD inhibit the normal function of CDKI, as diagrammed below. Wild type Kinase A activates mitosis Wild type CDKI inactivates mitosis Wild type Kinase A can inactivate CDKI H- Inhibits CDKI Kinase A Mitosis G2 G1 S-phase A) Would you expect these mutations in CDKI that lead to cancer to be dominant or recessive at tthe cellular level? Explain your thinking.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:Short Answer 2. You are studying the role of Kinase A and CDKI in neuroblastoma, a type of cancer. In neuroblastoma tumors, mutations are found in genes for both Kinase A and CDKI. CDKİ is a cell cycle inhibitor, and phosphorylation of CDKI by Kinase A will
inhibit the normal function of CDKI, as diagrammed below.
Wild type Kinase A activates mitosis
Wild type CDKİ inactivates mitosis
Wild type Kinase A can inactivate CDKI
H= Inhibits
CDKI
Kinase A
Mitosis
G1
G2
S-phase
A) Would you expect these mutations in CDKİ that lead to cancer to be dominant or recessive at tthe cellular level? Explain your thinking.
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