In the presence of saturating amounts of oxaloacetate, the activity of citrate synthase from pig heart tissue shows a sigmoid dependence on the concentration of acetyl-CoA. When succinyl-CoA is added, the curve shifts to the right and the sigmoid dependence is more pronounced. Choose the statements that are reasonable explanations for the right-ward shift of the velocity curve caused by succinyl-CoA. Succinyl-CoA competes with oxaloacetate for binding at the active site. Succinyl-CoA competes with acetyl-CoA for binding at the active site. Succinyl-CoA binds at a regulatory site other than the active site. Succinyl-CoA binds covalently to the enzyme. Succinyl-CoA competes with dissociation of CoA as a product of the reaction. Activity (% of Vmax) 100F No 80- 60- 40 succinyl-CoA I added 20 Succinyl-CoA L 1 L 20 40 60 80 100 120 [Acetyl-CoA] (μm)

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
icon
Related questions
icon
Concept explainers
Question

There are mulitple options. The second option alone is incorrect.

In the presence of saturating amounts of oxaloacetate, the
activity of citrate synthase from pig heart tissue shows a
sigmoid dependence on the concentration of acetyl-CoA.
When succinyl-CoA is added, the curve shifts to the right and
the sigmoid dependence is more pronounced.
Choose the statements that are reasonable explanations
for the right-ward shift of the velocity curve caused
by succinyl-CoA.
Succinyl-CoA competes with oxaloacetate for
binding at the active site.
Succinyl-CoA competes with acetyl-CoA for
binding at the active site.
Succinyl-CoA binds at a regulatory site other than
the active site.
Succinyl-CoA binds covalently to the enzyme.
Succinyl-CoA competes with dissociation of CoA as
a product of the reaction.
Activity (% of Vmax)
100F No
80-
60-
40
succinyl-CoA
I
added
20
Succinyl-CoA
L
1
1
20 40 60 80 100 120
[Acetyl-CoA] (μm)
Transcribed Image Text:In the presence of saturating amounts of oxaloacetate, the activity of citrate synthase from pig heart tissue shows a sigmoid dependence on the concentration of acetyl-CoA. When succinyl-CoA is added, the curve shifts to the right and the sigmoid dependence is more pronounced. Choose the statements that are reasonable explanations for the right-ward shift of the velocity curve caused by succinyl-CoA. Succinyl-CoA competes with oxaloacetate for binding at the active site. Succinyl-CoA competes with acetyl-CoA for binding at the active site. Succinyl-CoA binds at a regulatory site other than the active site. Succinyl-CoA binds covalently to the enzyme. Succinyl-CoA competes with dissociation of CoA as a product of the reaction. Activity (% of Vmax) 100F No 80- 60- 40 succinyl-CoA I added 20 Succinyl-CoA L 1 1 20 40 60 80 100 120 [Acetyl-CoA] (μm)
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 2 steps

Blurred answer
Knowledge Booster
Metabolic pathways
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education