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In questions 4-7, refer to the scheme below. Maxigesic is a combination analgesic containing acetaminophen (500 mg) and ibuprofen (150 mg) with a starch binder. Finish the flowchart to show how you could separate acetaminophen and ibuprofen using acid-base extractions. (Note: the pKa of ibuprofen is about 4.9 and the pKa of acetaminophen is 9.5). 4. Refer to letter A: Indicate the pH of a buffered aqueous solution that would selectively remove ibuprofen from the organic layer. 5. Refer to the funnel marked B: What compound is in the upper layer, and is it in an ionized or unionized form? 6. Refer to letter C: Indicate what solution is needed to cause the dissolved compound to precipitate, and identify the precipitate that forms. 7. Refer to letter D: Indicate what technique could be used to isolate the organic solid, and identify the solid that forms.

In questions 4-7, refer to the scheme below. Maxigesic is a combination analgesic containing acetaminophen (500 mg) and ibuprofen (150 mg) with a starch binder. Finish the flowchart to show how you could separate acetaminophen and ibuprofen using acid-base extractions. (Note: the pKa of ibuprofen is about 4.9 and the pKa of acetaminophen is 9.5). 4. Refer to letter A: Indicate the pH of a buffered aqueous solution that would selectively remove ibuprofen from the organic layer. 5. Refer to the funnel marked B: What compound is in the upper layer, and is it in an ionized or unionized form? 6. Refer to letter C: Indicate what solution is needed to cause the dissolved compound to precipitate, and identify the precipitate that forms. 7. Refer to letter D: Indicate what technique could be used to isolate the organic solid, and identify the solid that forms.

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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can you help with number 6. 

In questions 4-7, refer to the scheme below. Maxigesic is a combination analgesic containing acetaminophen (500 mg) and ibuprofen (150 mg) with a starch binder. Finish the flowchart to show how you could separate acetaminophen and ibuprofen using acid-base extractions. (Note: the pKa of ibuprofen is about 4.9 and the pKa of acetaminophen is 9.5). 4. Refer to letter A: Indicate the pH of a buffered aqueous solution that would selectively remove ibuprofen from the organic layer. 5. Refer to the funnel marked B: What compound is in the upper layer, and is it in an ionized or unionized form? 6. Refer to letter C: Indicate what solution is needed to cause the dissolved compound to precipitate, and identify the precipitate that forms. 7. Refer to letter D: Indicate what technique could be used to isolate the organic solid, and identify the solid that forms. ether Maxigesic tablet D technique: В top layer A sBu pH range: OH -NH bottom layer C solution to add:
Transcribed Image Text:In questions 4-7, refer to the scheme below. Maxigesic is a combination analgesic containing acetaminophen (500 mg) and ibuprofen (150 mg) with a starch binder. Finish the flowchart to show how you could separate acetaminophen and ibuprofen using acid-base extractions. (Note: the pKa of ibuprofen is about 4.9 and the pKa of acetaminophen is 9.5). 4. Refer to letter A: Indicate the pH of a buffered aqueous solution that would selectively remove ibuprofen from the organic layer. 5. Refer to the funnel marked B: What compound is in the upper layer, and is it in an ionized or unionized form? 6. Refer to letter C: Indicate what solution is needed to cause the dissolved compound to precipitate, and identify the precipitate that forms. 7. Refer to letter D: Indicate what technique could be used to isolate the organic solid, and identify the solid that forms. ether Maxigesic tablet D technique: В top layer A sBu pH range: OH -NH bottom layer C solution to add:
Expert Solution
Step 1

acid base extraction can be used to separate to organic compound on the basis of the acidity or basicity of the functional group

now as we know that organic compound are more  soluble in organic solvent  than in water solvent so to separate them we use base or acid so that they will be converted to their conjugate acid/base respectively and move to water phase

 

if the group to separated have acid group then on reaction with base the acidic proton will be lost and the conjugate base will be as salt so it will move to water phase and it will be extracted out

we would also carry out the same procedure with the help of acid if we have basic group to be separated out

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