In hepatocytes, the enzyme glucokinase catalyzes the ATP-coupled phosphorylation of glucose. Glucokinase binds both ATP and glucose, forming a glucose-ATP-enzyme complex. The enzyme then transfers the phosphoryl group directly from ATP to glucose. Select the advantages of phosphoryl group transfer compared to hydrolysis and subsequent phosphorylation? ATP hydrolysis is thermodynamically unfavorable compared to group transfer. Glucokinase increases the transition state energy, favoring glucose phosphorylation. The process takes advantage of the high phosphoryl group transfer potential of ATP. Reaction intermediates do not need to be present in excess. Incorrect
In hepatocytes, the enzyme glucokinase catalyzes the ATP-coupled phosphorylation of glucose. Glucokinase binds both ATP and glucose, forming a glucose-ATP-enzyme complex. The enzyme then transfers the phosphoryl group directly from ATP to glucose. Select the advantages of phosphoryl group transfer compared to hydrolysis and subsequent phosphorylation? ATP hydrolysis is thermodynamically unfavorable compared to group transfer. Glucokinase increases the transition state energy, favoring glucose phosphorylation. The process takes advantage of the high phosphoryl group transfer potential of ATP. Reaction intermediates do not need to be present in excess. Incorrect
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Transcribed Image Text:In hepatocytes, the enzyme glucokinase catalyzes the ATP-coupled phosphorylation of glucose. Glucokinase binds both ATP
and glucose, forming a glucose-ATP-enzyme complex. The enzyme then transfers the phosphoryl group directly from ATP
to glucose.
Select the advantages of phosphoryl group transfer compared to hydrolysis and subsequent phosphorylation?
ATP hydrolysis is thermodynamically unfavorable compared to group transfer.
Glucokinase increases the transition state energy, favoring glucose phosphorylation.
The process takes advantage of the high phosphoryl group transfer potential of ATP.
Reaction intermediates do not need to be present in excess.
Incorrect
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