In dogs (Canis familiaris), there is a hereditary deafness caused by the recessive gene d. A kennel owner has a male dog (Fido, of course) that she wants to use for breeding purposes. She comes to you for genetlc advice. The dog can hear, so you know that his genotype is either DD or Dd. If Fido's genotype were Dd, the owner would not use him for breeding so that the deafness gene will not be passed on. The dog's genotype can be ascertained via a test-cross with a deaf female (dd). Draw Punnett squares or pedigrees to illustrate these two possible crosses. O000 O a. Use fractions or decimals to indicate proportions: In each case, what proportion of the offspring would be expected to be hearing? b. What proportion would be expected to be deaf? c. How could you tell the genotype of the male dog (in parental generation P)? d. Also, using a Punnett square, how would you explain to the kennel owner that two hearing dogs could produce deaf offspring? Indicate to the kennel owner what kind(s) of gametes (ova or sperm) could hearing dogs produce to conceive a deaf puppy

Human Anatomy & Physiology (11th Edition)
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Chapter1: The Human Body: An Orientation
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Background
Problem N° 7
Objective: To illustrate the use of test
crosses to establish unknown genotypes.
In dogs (Canis familiaris), there is a hereditary deafness caused by the recessive gene d. A kennel owner has a
male dog (Fido, of course) that she wants to use for breeding purposes. She comes to you for genetlc advice. The
dog can hear, so you know that his genotype is either DD or Dd.
For this problem, you are allowed to use
Punnett squares or pedigrees.
If Fido's genotype were Dd, the owner would not use him for breeding so that the deafness gene will not be
passed on. The dog's genotype can be ascertained via a test-cross with a deaf female (dd). Draw Punnett squares
or pedigrees to illustrate these two possible crosses.
A test cross uses an individual whose
genotype we can be certain of, i.e., a
homozygous recessive for a particular trait.
Such organism is crossed with one whose
genotype we do not know (remember the
homozygous recessive always express the
recessive phenotype). In this case, a dd dog
will be deaf and a hearing dog can be DD or
Dd (i.e., D- represents both homozygous
dominant and heterozygous until the
genotype is determined).
O000
of
The results of a test cross will be either
dd X DD → All Dd (all hearing), the unkonwn
genotype is DD;
a. Use fractions or decimals to indicate proportions: In each case, what proportion of the offspring
would be expected to be hearing?
or
dd X Dd > % Dd + % dd (half hearing,
half deaf), the unknown
genotype is Dd.
b. What proportion would be expected to be deaf?
So, the proportion of hearing dogs will
indicate the unknown genotype.
c. How could you tell the genotype of the male dog (in parental generation P)?
d. Also, using a Punnett square, how would you explain to the kennel owner that two hearing dogs
could produce deaf offspring? Indicate to the kennel owner what kind(s) of gametes (ova or sperm)
could hearing dogs produce to conceive a deaf puppy
Transcribed Image Text:Background Problem N° 7 Objective: To illustrate the use of test crosses to establish unknown genotypes. In dogs (Canis familiaris), there is a hereditary deafness caused by the recessive gene d. A kennel owner has a male dog (Fido, of course) that she wants to use for breeding purposes. She comes to you for genetlc advice. The dog can hear, so you know that his genotype is either DD or Dd. For this problem, you are allowed to use Punnett squares or pedigrees. If Fido's genotype were Dd, the owner would not use him for breeding so that the deafness gene will not be passed on. The dog's genotype can be ascertained via a test-cross with a deaf female (dd). Draw Punnett squares or pedigrees to illustrate these two possible crosses. A test cross uses an individual whose genotype we can be certain of, i.e., a homozygous recessive for a particular trait. Such organism is crossed with one whose genotype we do not know (remember the homozygous recessive always express the recessive phenotype). In this case, a dd dog will be deaf and a hearing dog can be DD or Dd (i.e., D- represents both homozygous dominant and heterozygous until the genotype is determined). O000 of The results of a test cross will be either dd X DD → All Dd (all hearing), the unkonwn genotype is DD; a. Use fractions or decimals to indicate proportions: In each case, what proportion of the offspring would be expected to be hearing? or dd X Dd > % Dd + % dd (half hearing, half deaf), the unknown genotype is Dd. b. What proportion would be expected to be deaf? So, the proportion of hearing dogs will indicate the unknown genotype. c. How could you tell the genotype of the male dog (in parental generation P)? d. Also, using a Punnett square, how would you explain to the kennel owner that two hearing dogs could produce deaf offspring? Indicate to the kennel owner what kind(s) of gametes (ova or sperm) could hearing dogs produce to conceive a deaf puppy
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