In a study, an undergraduate student discovered a new enzyme involved in the metabolism ofserotonin. This enzyme is made up of 3 subunits of the same protein. To characterize thisenzyme, the student used genetic approaches to induce mutations in the coding region of thegene that codes for this protein and performed crosses to measure the effects of genotypes onenzyme activity.A) Indicate directly in the diagram (via a bar graph) the predicted relationship betweengenotype and enzyme activity. (Al represents the wild-type allele, A2 represents themutant allele).A2A2A1A2A1Α1B) Explain the reasoning for your prediction.Enzyme Activity

Enzymes are usually protein molecules which catalyzes several biochemical reactions. It works as a…

Answered: In a study, an undergraduate student…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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The beach mouse (Peromyscus polionotus) is a small rodent found in the southeastern United States. Coat color in the beach mouse is variable, from dark brown to blonde (Figure 1). A pigment called eumelanin is responsible for some of the diversity in mouse coat color. The MC1R gene, located on chromosome 8, plays a major role in the synthesis of eumelanin. There are two alleles of MC1R: R allele. Results in a functional MC1R protein that leads to stimulation of pigment production. This allele is found in dark colored mice. C allele. Results in a non-functional MC1R protein. Pigment production is, as a result, not stimulated. This allele is found in light colored mice. Figure 1. Beach mouse with light fur (left) and dark (right). These mice are hunted by visual predators like owls and fox. The distribution of coat color is not random. Beach mice with dark fur are found further inland, on dark brown soils while mice with light fur are found on beaches, where the sand is light brown.…
Orangutans are an endangered species in their natural environment (the islands of Borneo and Sumatra), and so a captive-breeding program has been established using orangutans currently held in zoos throughout the world. One component of this program is research into orangutan cytogenetics. This research has shown that all orangutans from Borneo carry one form of chromosome 2, as shown in the accompanying diagram, and all orangutans from Sumatra carry the other form. Before this cytogenetic difference became known, some matings were carried out between animals from different islands, and 14 hybrid progeny are now being raised in captivitya. What term or terms describe the differences between these chromosomes? b. Draw the chromosomes 2, paired in the first meiotic prophase, of such a hybrid orangutan. Be sure to show all the landmarks indicated in the accompanying diagram, and label all parts of your drawing. c. In 30 percent of meioses, there will be a crossover somewhere in the region…
To build a genetic map, how many types of crosses will be required to perform if you have three genes to map? Explain.
Imagine that you are a new breeder for caique parrots. You can sell normal green feather birds for $500 a bird. The mutation for blue feathers is rare and birds with this color can sell for $3000 a bird. Your goal is to produce as many blue feather offspring as you can, but you don't have the budget to buy blue feather birds as parents. Question: What genotype should you purchase for both parent blrds to get the best chance of getting blue feather offspring? Create and use your Punnett square results as evidence to support your answer. You will need to make multiple Punnett Squares to see which parent genotypes makes the most blue feathered offspring. Keep in mind that Green fealhers (G) is dominant over blue feathers (g), so birds with blue feathers have the genotype gg. Some Punnett squares are provided for you to determine the possible crosses, but remember yoU cannot afford a blue feathered bird, so neither of your parent birds can have the genotype gg. Complete a Punnett Square…
A cytogeneticist has collected tissue samples from members of a certain butterfly species. Some of the butterflies were located in Canada, and others were found in Mexico. Through karyotyping, the cytogeneticist discovered that chromosome 5 of the Canadian butterflies has a large inversion compared with chromosome 5 of the Mexican butterflies. The Canadian butterflies were inversion homozygotes, whereas the Mexican butterflies had two normal copies of chromosome 5. 1) Would a cross between Mexican and Canadian butterflies produce phenotypically normal offspring? and 2) Would the offspring of the cross (so F2 generation) be fertile?
During the course of a research project you generate a gene knockout line in Arabidopsis thaliana to study the function of a gene you believe plays a crucial role in cellular metabolism. You note that the initial transformants are a bit smaller than normal. In subsequent crosses you are unable to isolate homozygotes for the knockout allele. Heterozygotes in subsequent generation are still a bit smaller than the homozygous wild type plants. Explain what is happening.
The beach mouse (Peromyscus polionotus) is a small rodent found in the southeastern United States. Coat color in the beach mouse is variable, from dark brown to blonde (Figure 1). A pigment called eumelanin is responsible for some of the diversity in mouse coat color. The MC1R gene, located on chromosome 8, plays a major role in the synthesis of eumelanin. There are two alleles of MC1R: R allele. Results in a functional MC1R protein that leads to stimulation of pigment production. This allele is found in dark colored mice. C allele. Results in a non-functional MC1R protein. Pigment production is, as a result, not stimulated. This allele is found in light colored mice. Figure 1. Beach mouse with light fur (left) and dark (right). These mice are hunted by visual predators like owls and fox. The distribution of coat color is not random. Beach mice with dark fur are found further inland, on dark brown soils while mice with light fur are found on beaches, where the sand is…
This research exploited the principles of Mendelian genetics combined with the MCR technique to genetically manipulate fruit flies. Now, suppose you do a similar experiment. You perform two crosses: one that allows for Mendelian patterns of inheritance, and another that uses MCR with CRISPR-Cas9 to genetically edit the eye color of fruit flies. In fruit flies, the gene for eye color is located on the X chromosome. Red eyes (wild type, w+) are dominant to white eyes (mutant, w-). Let’s see how well you can predict genotype and phenotype ratios resulting from the two crosses. Genetic cross 1 (without MCR): Cross between a white-eyed male and a homozygous red-eyed female. Genetic cross 2 (with MCR): Cross between an MCR-element (carries the CRISPR-Cas9 construct) white-eyed male and a homozygous red-eyed female. Keep in mind, this technology converts a heterozygous genotype to a homozygous recessive genotype. Drag the labels to the table to fill in the genotypic and phenotypic ratios.
A defective gene on chromosome 15 causes Tay-Sachs disease. It is a central nervous system neurodegenerative disease that most often affects infants, though older children and adults can have late-onset forms of the disease. The defective gene prevents the body from making a protein called hexosaminidase A. Without, hexosaminidase A, chemicals called gangliosides build up in the nerve cells of the brain, destroying brain cells. Pedigree information regarding the incidence of Tay-Sachs within a family is depicted above. The row below that indicates the genotypes of individuals II-1, II-2, and III-1 is Select one: a. II-1 II-2 III-1 Aa Aa aa b. II-1 II-2 III-1 XAY XAXa XAXa c. II-1 II-2 III-1 XAY XAXA XaXa d. II-1 II-2 III-1 AA aa Aa
In a three-point mapping experiment for the genes a-w-ec, the following percentages of events are observed: NCO events: 57%; SCO events between a and w: 18%; SCO events between w and ec: 22%; DCO events: 2% Assuming that w is in the middle, what is the map distance between w and ec? What is the map distance between a and w? Draw the map.
A representation of the distance between genes or genetic markers is called a?
Which of the following patterns was observed, in the experiments of Hershey and Chase, using the T2 bacteriophage of E. coli? radioactive proteins were passed on to viral progeny, but not radioactive polynucleotides radioactive polynucleotides were passed on to viral progeny, but not radioactive proteins both radioactive proteins and radioactive polynucleotides were passed on to viral progeny both radioactive polynucleotides and radioactive proteins were passed on to viral progeny neither radioactive proteins nor radioactive polynucleotides were passed on to viral progeny

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