If, in addition to the constraints on glucose concentration listed previously, we have in the liver cell ATP concentration == 5 mM and ADP concentration == 5 mM, what is the theoretical concentration of glucose-6-phosphate at equilibrium at pH=7.4 and 37 ∘C? Express your answer to three significant figures and include the appropriate units
If, in addition to the constraints on glucose concentration listed previously, we have in the liver cell ATP concentration == 5 mM and ADP concentration == 5 mM, what is the theoretical concentration of glucose-6-phosphate at equilibrium at pH=7.4 and 37 ∘C? Express your answer to three significant figures and include the appropriate units
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
Related questions
Question
Solve Part C.
If, in addition to the constraints on glucose concentration listed previously, we have in the liver cell ATP concentration == 5 mM and ADP concentration == 5 mM, what is the theoretical concentration of glucose-6-phosphate at equilibrium at pH=7.4 and 37 ∘C?
Express your answer to three significant figures and include the appropriate units.
![The first reaction in glycolysis is the phosphorylation of glucose:
This is a thermodynamically unfavorable process, with AG" = +13.8 kJ/mol.
Part A
Submit Previous Answers
In a liver cell at 37 °C the concentrations of both phosphate and glucose are normally maintained at about 5 mM each. What would be the equilibrium concentration of glucose-6-phosphate,
according to the above data?
Express your answer to two significant figures and include the appropriate units.
Equilibrium concentration = 1.2x10-7 M
Correct
glucose + P₁ → G6P + H₂O
Keq
[G6P]
=
=
=
=
[G6P] [H₂O]
[glucose] [Pi]
AG
e RT
AG 13.8 kJ/mol
Note: in the biochemical standard state, the activity of H₂O is assigned a value of 1.
[G6P] (1)
(0.005) (0.005)
Pi + glucose →→→→glucose-6-phosphate + H₂O
13.8
= e 0.008314x310
=
-5.36
0.000025 x e
1.2 x 10-7 M
Ieview](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F5a9af09e-2dc3-4e5d-aa22-6229258bab20%2F8d8deb0b-3d8f-43df-a2d0-fcf7ad2b9417%2F2uyenjf_processed.png&w=3840&q=75)
Transcribed Image Text:The first reaction in glycolysis is the phosphorylation of glucose:
This is a thermodynamically unfavorable process, with AG" = +13.8 kJ/mol.
Part A
Submit Previous Answers
In a liver cell at 37 °C the concentrations of both phosphate and glucose are normally maintained at about 5 mM each. What would be the equilibrium concentration of glucose-6-phosphate,
according to the above data?
Express your answer to two significant figures and include the appropriate units.
Equilibrium concentration = 1.2x10-7 M
Correct
glucose + P₁ → G6P + H₂O
Keq
[G6P]
=
=
=
=
[G6P] [H₂O]
[glucose] [Pi]
AG
e RT
AG 13.8 kJ/mol
Note: in the biochemical standard state, the activity of H₂O is assigned a value of 1.
[G6P] (1)
(0.005) (0.005)
Pi + glucose →→→→glucose-6-phosphate + H₂O
13.8
= e 0.008314x310
=
-5.36
0.000025 x e
1.2 x 10-7 M
Ieview
Transcribed Image Text:This very low concentration of the desired product would be unfavorable for glycolysis. In fact, the reaction is coupled to ATP hydrolysis to give the overall reaction
ATP + glucose
glucose-6-phosphate + ADP + H+
What is AGO for the coupled reaction?
Express your answer to three significant figures and include the appropriate units.
AGO!= -18.4
Submit
kJ
mol
Part C
Previous Answers
Correct
ATP + H₂O → ADP +P; +H+
AG = -32.2 kJ/mol
Glucose + P₁ → G6P+H₂O
AGO! = +13.8 kJ/mol
ATP + glucose → ADP +G6P+H+ AG" =−18.4 kJ/mol
If, in addition to the constraints on glucose concentration listed previously, we have in the liver cell ATP concentration = 5 mM and ADP concentration = 5 mM, what is the theoretical
concentration of glucose-6-phosphate at equilibrium at pH = 7.4 and 37 °C?
Express your answer to three significant figures and include the appropriate units.
μA
Theoretical concentration = Value
Units
?
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
This is a popular solution!
Trending now
This is a popular solution!
Step by step
Solved in 4 steps with 7 images
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.Recommended textbooks for you
Chemistry
Chemistry
ISBN:
9781305957404
Author:
Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:
Cengage Learning
Chemistry
Chemistry
ISBN:
9781259911156
Author:
Raymond Chang Dr., Jason Overby Professor
Publisher:
McGraw-Hill Education
Principles of Instrumental Analysis
Chemistry
ISBN:
9781305577213
Author:
Douglas A. Skoog, F. James Holler, Stanley R. Crouch
Publisher:
Cengage Learning
Chemistry
Chemistry
ISBN:
9781305957404
Author:
Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:
Cengage Learning
Chemistry
Chemistry
ISBN:
9781259911156
Author:
Raymond Chang Dr., Jason Overby Professor
Publisher:
McGraw-Hill Education
Principles of Instrumental Analysis
Chemistry
ISBN:
9781305577213
Author:
Douglas A. Skoog, F. James Holler, Stanley R. Crouch
Publisher:
Cengage Learning
Organic Chemistry
Chemistry
ISBN:
9780078021558
Author:
Janice Gorzynski Smith Dr.
Publisher:
McGraw-Hill Education
Chemistry: Principles and Reactions
Chemistry
ISBN:
9781305079373
Author:
William L. Masterton, Cecile N. Hurley
Publisher:
Cengage Learning
Elementary Principles of Chemical Processes, Bind…
Chemistry
ISBN:
9781118431221
Author:
Richard M. Felder, Ronald W. Rousseau, Lisa G. Bullard
Publisher:
WILEY