Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Transcribed Image Text:### Educational Content: Stereochemistry Practice Problems
#### 9. Identify the Indicated Groups in the Following Molecules as pro-R or pro-S:
The problem features several molecular structures where specific groups are indicated with arrows. The task is to determine whether these groups are pro-R or pro-S, which involves assessing the potential chirality center configuration if the group were replaced by a higher priority substituent.
1. **Molecule 1**:
- Contains an amide group within a five-membered ring. The indicated group (arrow pointing to the hydrogen) is labeled as pro-R.
2. **Molecule 2**:
- A cyclic compound with an aldehyde (CHO) group. The hydrogen indicated by the arrow is not labeled, but assessment involves determining if a switch would lead to an R-configuration.
3. **Molecule 3**:
- A chain structure with a hydrogen indicated and two methyl groups adjacent. The task involves deciding pro-R or pro-S.
4. **Molecule 4**:
- A structure with a bromide group attached. One hydrogen is indicated; assign pro-R or pro-S.
5. **Molecule 5**:
- A cyclic ester-like structure. The indicated hydrogen is part of a chiral center under consideration for pro-R or pro-S labeling.
6. **Molecule 6**:
- Has a phenyl (Ph) group. The hydrogen indicated is one of the substituents, needing pro-R or pro-S assessment.
7. **Molecule 7**:
- Ethers with two oxygens in a three-membered ring. The configuration is assessed similarly.
8. **Molecule 8**:
- An acidic group is present (CO₂H). Assessment of indicated hydrogen involves determining if it will be pro-R or pro-S.
#### 10. Identify the Indicated Faces in the Following Molecules as Re or Si:
A series of molecular structures is presented, with specific faces indicated for stereochemical designation:
- **Molecule 1**:
- A molecule with labeling arrows pointing to faces needing evaluation depending on potential substituent arrival to result in re or si chirality.
- **Molecule 2**:
- Similar analysis is necessitated without specific molecular detail here.
### Explanation of Terms:
- **pro-R and pro-S**: Refer to the potential stereochemical outcome if replacing
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