Answered: Hutchinson-Gilford progeria syndrome is…

MATLAB: An Introduction with Applications

6th Edition

ISBN:9781119256830

Author:Amos Gilat

Publisher:Amos Gilat

Chapter1: Starting With Matlab

Section: Chapter Questions

Problem 1P

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Question

Hutchinson-Gilford progeria syndrome is a rare genetic condition that produces rapid aging in children. In individuals with this syndrome, cardiovascular disease is a common cause of death in the teenage years. A clinical study examined the effect of treatment with the drug lonafarnib on a number of physiological outcomes. The researchers measured the pulse wave velocity (PWV) of 18 children diagnosed with progeria and recruited worldwide.

The study reports that the mean PWV of 18 children diagnosed with progeria is 12.44 m/s, and the standard deviation is 3.638 m/s.

Assuming that PWV is normally distributed, is there significant evidence that the mean PWV of children with progeria is abnormally high (i.e. greater than 6.6 m/s)?

Let � (pronounced as "mu") be the true mean PWV of children with progeria.

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What are the decision about H₀ and conclusion?

Definition Definition Measure of central tendency that is the average of a given data set. The mean value is evaluated as the quotient of the sum of all observations by the sample size. The mean, in contrast to a median, is affected by extreme values. Very large or very small values can distract the mean from the center of the data. Arithmetic mean: The most common type of mean is the arithmetic mean. It is evaluated using the formula: μ = 1 N ∑ i = 1 N x i Other types of means are the geometric mean, logarithmic mean, and harmonic mean. Geometric mean: The nth root of the product of n observations from a data set is defined as the geometric mean of the set: G = x 1 x 2 ... x n n Logarithmic mean: The difference of the natural logarithms of the two numbers, divided by the difference between the numbers is the logarithmic mean of the two numbers. The logarithmic mean is used particularly in heat transfer and mass transfer. ln x 2 − ln x 1 x 2 − x 1 Harmonic mean: The inverse of the arithmetic mean of the inverses of all the numbers in a data set is the harmonic mean of the data. 1 1 x 1 + 1 x 2 + ...

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