How tumor-suppressor genes contribute to cancer whenmutated or abnormally expressed ?

Q: Describe the general process of cell signalling pathways: what events take place for a signal to…

A: * mainly there are Three Stages of Cell Signaling . The first one is reception and here the signal…

Q: Why is it harder to develop a drug that targets a tumor suppressor gene compared to an oncogene…

A: Uncontrolled cell division in the cells may result into the tumor formation. Sometimes the cells may…

Q: Which genetic cancer predisposition syndrome is caused by germ-line mutations in the p53 gene and is…

A: P53 is the tumor suppressor protein (TP53 in humans) which is also described as the guardian of the…

Q: Define Suppressor Mutations.

A: Suppressor mutations are helpful for distinguishing new genetic sites that have an effect on a…

Q: What is/are the role/s of molecular techniques in understanding cancer? Cite some references from…

A: In cancer, cells grow abnormally. Cancer is not one disease. It is a group of diseases. The…

Q: Distinguish between proto-oncogenes and tumor-suppressor genes. To become cancer promoting, do…

A: Oncogene is a type of gene having the ability which can develop a cell to a tumor cell when…

Q: How does the epithelial-to-mesenchymal transition (EMT) contribute to tumorigenesis and disease…

A: Epithelial-mesenchymal transition (EMT) could be a method within which epithelial cells acquire…

Q: Explain how epigenetic changes can contribute to tumorigenesis.

A: Tumors are clumps of cells formed by uncontrollable cell division. Tumorigenesis is the uncontrolled…

Q: Genetic tests that detect mutations in the BRCA1 and BRCA2 tumor-suppressor genes are widely…

A: Answer: Introduction: The genes like the breast cancer 1 (BRCA1) and breast cancer 2 (BRCA2) genes…

Q: Tissues and differentiation a)Explain what is meant by termination and differentiation ).b) Explain…

A: The question has been assumed to be "a)Explain what is meant by determination and…

Q: Metastasis occurs when cells from a primary tumor invade and colonize other tissues. Metastasis is a…

A: Metastasis is a critical process in cancer progression where cancer cells from a primary tumor site…

Q: Describe the key characteristics of cancer.

A: The tumor is the large mass of the tissue formed by the repeated division of the cell. It is of two…

Q: Is PI3K a proto-oncogene or a tumor suppressor gene? Why

A: PI3K means Phospho inositol 3 kinase gene.It is involved in signalling pathways.It is the mutation…

Q: Describe the common signal transduction event that is perturbed by cancer-promoting mutations in the…

A: Neurofibromatosis type 1 (NF1) is a genetic disorder that runs in families. Peripheral…

Q: How do BRCA1 and BRCA2 function in regard to cell proliferation (are they proto-oncogenes,…

A: jjBRCA proteins play an important role in a variety of biological functions. In response to DNA…

Genomic studies

Genomic studies (genomics) is the study of the whole genome of an organism. Using bioinformatics and high-performance computing, genomic researchers examined massive amounts of deoxyribonucleic acid (DNA)-sequence data to discover variations or mutations that affect drug response, health, or disease. Genomics is a much younger discipline than genetics, having only emerged in the last few decades as a result of technological advancements in DNA sequencing and computational biology.