HO(c) (1 pt) Both of the following are hydride donors. Circle the harder nucleophileof-P-Cu-HH+H-AI-HH(d) (4 pts) The following reaction involves two steps. Draw the anionic intermediate thatforms after sodium hydride reacts and the final organic product.Hints: what type of nucleophile is NaH and where does that mean it will react? Also, thesecond step is not a proton transfer. What's the most likely reaction for that intermediateto undergo?NaHanionic intermediatefinal product

In general, a 'hard' nucleophile is one that is small, highly charged, and does not have accessible…

Answered: HO (c) (1 pt) Both of the following are…

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter20: Acidity And Pka Of Phenols

Section: Chapter Questions

Problem 11E

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10:54 ← Question 21 of 32 Draw the major product of this reaction. Ignore inorganic byproducts. Submit Assume that the water side product is continuously removed to drive the reaction toward products. (CH3)2NH, TSOH Select to Draw | I I
Step 4a: Classify step. The target product is present, but the reaction is not over. The ethoxide ion has been regenerated. :0: :0: What is the key process in the next step of the mechanism? proton transfer formation of a o bond between nucleophile and electrophile loss of a leaving group carbocation rearrangement (e.g., methyl or hydride shift)
Classify each of the following organic reactions. reaction Hör H₂O 1) Hg(OAc)₂, H₂O aveau Br OH OH type of reaction (check all that apply) Odihydroxylation addition hydrogenation Dhalogenation halohydrin formation. subtraction halogenation hydrogenation addition halohydrin formation inhalation Odihydroxylation addition hydrogenation oxyhydration halogenation
6. The following reaction is an example of OH A) SN1 B) SN2 Br NaOH EtOH C) E1 D) E2 7. In the above reaction (Q6), what is the role of NaOH? A) It acts as an acid and reacts with EtOH B) It acts as nucleophile and attacks on electrophilic carbon in bromoprop C) It acts as a base and reacts with phenolic OH and forms phenolate ion D) It acts as a spectator
Which sequence of reactions will complete the transformation below? 1) BH3-THF, 2) NaOH, HOOH, 3) NaOEt 1) HBr, 2) ethanol, heat 1) BH3-THF, 2) HOOH, NaOH, 3) NaH (strong base), 4) ethyl iodide 1) HBr, ROOR, heat, 2) NaOEt OHBr, ethanol, heat LOCH₂CH3
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4. A CHEM 245 student wants to synthesize some ethylene glycol to use as antifreeze in his radiator this winter. He proposes the following reaction to his instructor, who quickly explains that this reaction won't work as proposed due to the student's choice of reagent. 1) NaH 2) H20 OH Но a) Why can't sodium hydride (NaH) be used as the nucleophile in the reaction above? b) Propose an alternate reagent that COULD be used with the ethylene oxide to successfully give the desired ethylene glycol product.
Under the conditions shown below, which anion would be the best nucleophile? "Triflate" is a good leaving group "Triflate" = -oso,CF₂ OSO₂CF3 To NUⓇ CH₂CH₂OH prasi b) Clo Nu Fo -3-0-9-CF₂ O d) Bre SNI 2-ster . 30251 4 • protic shiess
Under acid-catalyzed conditions, epoxides can be opened by a variety of nucleophiles other than water, such as alcohols. In such a case, the nucleophile will generally attack at the more substituted position. Using this information, predict the products for each of the following reactions (a-b): ? 1) RCO-H 2) [H₂SOJ Modify the given structure to draw the major product(s). Use the single bond tool to interconvert between double and single bonds. If a racemic mixture of enantiomers is expected, draw both enantiomers. Note: you can select a structure and use Copy and Paste to save drawing time. CH₂ Edit Drawing A
Acyl transfer (nucleophilic substitution at carbonyl) reactions proceed in two stages via a "tetrahedral intermediate." Draw the tetrahedral intermediate as it is first formed in the following reaction. CI H₂N OH • You do not have to consider stereochemistry. • Include all valence lone pairs in your answer. • Do not include counter-ions, e.g., Na+, I, in your answer. • In cases where there is more than one answer, just draw one. Sn [F
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