Which of the following statements concerning uncompetitive inhibitors is NOT true? a. They decrease the Km O b. They bind to both ES and Enzyme O c. They decrease the Vmax Od. They bind to ES only O e. No product is formed after their binding
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- Which one of the following best explains the distinctive effect of an uncompetitive inhibitor on Km, according to our coverage? If S binds first, I may never bind and P can be formed. When ESI complexes form, S is trapped and it is as though there is a lower concentration of E.3. In this question you can do the graphs on your computer. A, Calculate the Vmax and Km in the presence and absence of the inhibitor. B. Determine what type of inhibitor has been added. C. Determine the rate in the absence of inhibitor when the substrate concentration is 100mM. [S]mM 2.3 3.2 4 8 10 1/[S] MM-1 0.44 0.31 0.25 0.125 0.1 SIN INHIBIDOR Vo μmol/sec 1/Vo sec/μmol 0.25 0.29 X 0.4 X 4 3.5 X 2.5 X CON INHIBIDOR Vo μmol/sec1/Vo sec/μmol X X 0.17 0.29 X X X 4 3.5 XDrugs that inhibit eicosanoids formation may be... * agents reducing substrate arachidonic acid availability agents inhibiting the cyclooxygenase or lipoxygenase enzymes or both agents blocking eicosanoid receptors. O all of them
- Which phrase characterizes a uncompetitive inhibitor? OA. binds either enzyme or enzyme-substrate complex when present, Km of an enzyme will appear to decrease OB. when present, Km of an enzyme will either increase or decrease when present, Km of an enzyme will appear to increase OD.1. A competitive inhibitor for an enzyme a. b. C. d. e. changes the apparent Km but has no effect on Vmax. alters Vmax but has no effect on Km. is competitive with respect to substrate for binding to the enzyme active site. Answers a and care both correct. Answers b and care both correct.Describe the mechanism of toxicity of P=S organophosphates insecticides (e. g. parathion) in the body of an insect
- Which of the folowing types of inhibitors binds to the active site of an enzyme? Select one: a. Competitive b. All of them C. Uncompetitive O d. NoncompetitiveA hydrophilic drug A.Has a high reabsorption in renal tubules B.Has a low ability to penetraye the cell membrane C.Can cross the blood brain barrier easily D.Can bind to intracellular receptors. 2.The phase 1 reaction most often performed by mixed function CYP450 hepatic microsomal enzyme is A.Glucuronidation B.Oxidation C.Reduction D.Acetylation 3.CYP1A2 is involved in the metabolizing of several clinically important xenobiotics such as A.Caffeine B.Morphine C.Aspirin D.Alcohol 4.Drug metabolism,the drug.......undergoes phase 2(acetylation)before undergoing phase 1 (hydrolysis) metabolic reactions A Aspirin B.Codeine C.Isoniazid D.Diazepam E.Phenytoin 5.Which of the following statements is/are true regarding the oxidation of aromatic rings A.Electron donating substituents promote oxidationat the meta position B.Electron withdrawing substituents promote oxidation at the meta position C.All aromatic rings in a molecule are hydroxylated D Monosubstituted aromatic rings can be…Iron binds to enzyme X. This metal most likely acts as Select one: O A. nonprotein coenzyme O B. competitive inhibitor of the enzyme O C. cofactor that increases the enzymatic activity O D. vitamin-derived cofactor O E. noncompetitive inhibitor of the enzyme
- Proteases are one of the main drug targets. Choose the False statement regarding proteases. A. Proteases are enzymes that cleave peptide bonds. B. Water is a reactant in the reaction catalyzed by proteases. C. Proteases, like all enzymes show substrate specificity, meaning they cleave only substate that fit the bonding product. D. Proteases rely on the proton transfer from NADH to the substrate. E. Protease mechanism involves only acid-base catalysis.Penícillin is an esxample of what type of enzyme inhíbitor? A. Competitive B. Noncompetitive C. Uncompetitive D. Irreveralble What type of Inhíbition ia observed from the ahift of the Lineweaver-Burke plot ahown in the graph below where the solid line represents the uninhibited enzymatic reaction while the broken line represents the inhibited enzymatic reaction? A. Irreveraible inhibition B. Noncompetitive inhibition C. Competitive inhíbition D. Uncompetitive inhibition Potaszium cyanide ia a polzon which combines with cytochrome A3 to prevent binding of oxygen to the enzyme without altering the Km of the reaction with reapect to reduced cytochrome c. Which type of inhíbition does this represent? 9. A. Irreveraible inhibition B. Noncompetitive inhibition C. Competitive inhibition D. Uncompetitive inhibition Which of the following enzyme clesses catalyze reactions in which two molecules become diasociated from each other? 10. A. Kinase В. Нydrolaae C. Isomerase D. Ligase 1. Which of the…Write Cifonly statement A is correct, Hif only statement B is correct, Eif both statements are correct, Mif both statements are incorrect. A. When an inhibitor binds to the enzyme-substrate complex, the inhibition mode is uncompetitive. B. As a consequence, the enzyme's efficiency is decreased along with the maximum velocity.