"hich of the compounds below would be a major product of the following reaction? (1) NABH4(excess)/EIOH OCH3 (2) dil. H*/H,0 он он HO HO OCH3 Compound A Compound B Compound C Compound D Compound B O Compound A Compound D Compound C

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### Reaction Analysis: Major Product Determination

#### Question
Which of the compounds below would be a major product of the following reaction?

#### Reaction Conditions
1. \( \text{NaBH}_4 \) (excess) / \(\text{EtOH}\)
2. Dilute \( \text{H}^+ / \text{H}_2\text{O} \)

#### Reaction Scheme
Initial structure: 
- Cyclopentane derivative with a ketone and a methoxy group.

#### Possible Products

- **Compound A**: 
  - Cyclopentanol structure with two hydroxyl groups (diol).
  
- **Compound B**: 
  - Structure retains methoxy group, and an additional hydroxyl group is present in a specific orientation.
  
- **Compound C**: 
  - Cyclopentane structure with methoxy and hydroxyl groups in a different stereochemical arrangement.
  
- **Compound D**: 
  - Cyclopentanone structure with a single ketone.

#### Options
- ○ Compound B
- ○ Compound A
- ○ Compound D
- ○ Compound C

---

### Explanation
The reaction involves the use of sodium borohydride (\( \text{NaBH}_4 \)) in ethanol, which is a mild reducing agent typically employed to reduce ketones to alcohols. This reaction is followed by an acidic water workup.

**Expected Outcome:**
Considering the reduction potential of \( \text{NaBH}_4 \), it will likely result in the reduction of the ketone group in the starting material. This process typically forms alcohols by converting carbonyl groups to hydroxyl groups while leaving most ether linkages (like methoxy groups) intact.

Based on the structural analysis of the possible products and the reaction conditions, analyze which compound corresponds to the described transformation.

### Conclusion
Analyzing each option's structures against the expected type of reduction and given the description of \( \text{NaBH}_4 \)'s activity, the correct answer should be selected by considering which structure reflects the transformation of a ketone to its respective alcohol, maintaining the other functional groups unchanged.
Transcribed Image Text:### Reaction Analysis: Major Product Determination #### Question Which of the compounds below would be a major product of the following reaction? #### Reaction Conditions 1. \( \text{NaBH}_4 \) (excess) / \(\text{EtOH}\) 2. Dilute \( \text{H}^+ / \text{H}_2\text{O} \) #### Reaction Scheme Initial structure: - Cyclopentane derivative with a ketone and a methoxy group. #### Possible Products - **Compound A**: - Cyclopentanol structure with two hydroxyl groups (diol). - **Compound B**: - Structure retains methoxy group, and an additional hydroxyl group is present in a specific orientation. - **Compound C**: - Cyclopentane structure with methoxy and hydroxyl groups in a different stereochemical arrangement. - **Compound D**: - Cyclopentanone structure with a single ketone. #### Options - ○ Compound B - ○ Compound A - ○ Compound D - ○ Compound C --- ### Explanation The reaction involves the use of sodium borohydride (\( \text{NaBH}_4 \)) in ethanol, which is a mild reducing agent typically employed to reduce ketones to alcohols. This reaction is followed by an acidic water workup. **Expected Outcome:** Considering the reduction potential of \( \text{NaBH}_4 \), it will likely result in the reduction of the ketone group in the starting material. This process typically forms alcohols by converting carbonyl groups to hydroxyl groups while leaving most ether linkages (like methoxy groups) intact. Based on the structural analysis of the possible products and the reaction conditions, analyze which compound corresponds to the described transformation. ### Conclusion Analyzing each option's structures against the expected type of reduction and given the description of \( \text{NaBH}_4 \)'s activity, the correct answer should be selected by considering which structure reflects the transformation of a ketone to its respective alcohol, maintaining the other functional groups unchanged.
Expert Solution
Step 1

NaBH4 is less reactive thus it can't reduce ester but it reduces ketones to their corresponding alcohol.

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