When 100 mg of a drug is administered as an IV bolus dose, the plasma concentrations (ug/mL) observed over time (hr) can be described by the following equation: C = 3.6e-0.105t C= 3-6e AUC 36 6 -0.105t 5. Calculate AUC(0-0) 0-105 = 34.28 6. What is the volume of distribution? Dose 100 VD= Co 3-6 7. Calculate the clearance of this drug. CI = KXVD CI = 0•105 x 27-8 %3D %3D Cl=2.9 8. What IV dose would be required to produce an initial plasma concentration of 10 ug/mL?
When 100 mg of a drug is administered as an IV bolus dose, the plasma concentrations (ug/mL) observed over time (hr) can be described by the following equation: C = 3.6e-0.105t C= 3-6e AUC 36 6 -0.105t 5. Calculate AUC(0-0) 0-105 = 34.28 6. What is the volume of distribution? Dose 100 VD= Co 3-6 7. Calculate the clearance of this drug. CI = KXVD CI = 0•105 x 27-8 %3D %3D Cl=2.9 8. What IV dose would be required to produce an initial plasma concentration of 10 ug/mL?
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Transcribed Image Text:When 100 mg of a drug is administered as an IV bolus dose, the plasma concentrations
(ug/mL) observed over time (hr) can be described by the following equation:
C = 3.6e-0.105t
C= 3-6e
AUC 36 6
-0.105t
5. Calculate AUC(0-0)
0-105
= 34.28
6. What is the volume of distribution?
Dose
100
VD=
Co
3-6
7. Calculate the clearance of this drug.
CI = KXVD
CI = 0•105 x 27-8
%3D
%3D
Cl=2.9
8. What IV dose would be required to produce an initial plasma concentration of 10
ug/mL?
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