H11.38 - Level 2 Unanswered • 3 attempts left Which of the following reactions would NOT have a "proton transfer step" in the reaction mechanism: 2-bromo-2-methylbutane + A H2O →2-methyl-2-butanol 2-bromobutane + NaOH → В (E)-2-butene 1-bromobutane + NaOMe → C methoxy butane 2-bromo-2-methylbutane + tert- D butoxide → 2-methyl-1-butene

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### H11.38 - Level 2

#### Question:

Which of the following reactions would NOT have a “proton transfer step” in the reaction mechanism:

#### Answer Choices:
- **A**: 2-bromo-2-methylbutane + H₂O → 2-methyl-2-butanol
- **B**: 2-bromobutane + NaOH → (E)-2-butene
- **C**: 1-bromobutane + NaOMe → methoxy butane
- **D**: 2-bromo-2-methylbutane + tert-butoxide → 2-methyl-1-butene

### Explanation:

This question is designed to assess your understanding of reaction mechanisms, specifically focusing on whether a proton transfer step is involved. Proton transfer steps commonly occur in many organic reactions and can significantly influence the reaction pathway and final products. Review the mechanisms for the reactions listed and analyze if they include a step where a proton (H⁺) is transferred from one entity to another.

### Detailed Analysis:

Each reaction involves different reagents and conditions. Carefully examine the structure and possible intermediates to determine the mechanism:

- **Option A**: Involves hydrolysis of an alkyl halide, which typically includes a proton transfer step.
- **Option B**: Involves elimination (E2) with a base, which may not necessarily involve a proton transfer.
- **Option C**: Involves substitution with a nucleophile, usually involving a proton transfer step.
- **Option D**: Involves a strong base leading to an elimination reaction, which usually does not involve a proton transfer.

Understanding these mechanisms will help you determine which reaction does not include a proton transfer step.
Transcribed Image Text:### H11.38 - Level 2 #### Question: Which of the following reactions would NOT have a “proton transfer step” in the reaction mechanism: #### Answer Choices: - **A**: 2-bromo-2-methylbutane + H₂O → 2-methyl-2-butanol - **B**: 2-bromobutane + NaOH → (E)-2-butene - **C**: 1-bromobutane + NaOMe → methoxy butane - **D**: 2-bromo-2-methylbutane + tert-butoxide → 2-methyl-1-butene ### Explanation: This question is designed to assess your understanding of reaction mechanisms, specifically focusing on whether a proton transfer step is involved. Proton transfer steps commonly occur in many organic reactions and can significantly influence the reaction pathway and final products. Review the mechanisms for the reactions listed and analyze if they include a step where a proton (H⁺) is transferred from one entity to another. ### Detailed Analysis: Each reaction involves different reagents and conditions. Carefully examine the structure and possible intermediates to determine the mechanism: - **Option A**: Involves hydrolysis of an alkyl halide, which typically includes a proton transfer step. - **Option B**: Involves elimination (E2) with a base, which may not necessarily involve a proton transfer. - **Option C**: Involves substitution with a nucleophile, usually involving a proton transfer step. - **Option D**: Involves a strong base leading to an elimination reaction, which usually does not involve a proton transfer. Understanding these mechanisms will help you determine which reaction does not include a proton transfer step.
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