Given a tripeptide Cys-His-Lys,   Cys: Pk1 = 1.71; Pk2 = 10.78; PkR = 8.33 His: Pk1 = 1.82; Pk2 = 9.17; PkR = 6.0 Lys: Pk1 = 2.18; Pk2 = 8.95; PkR = 10.53   draw the protonic equilibria for the tripeptide what is the IpH?

Q: When human hemoglobin undergoes a mutation, the mutant protein usually does not replace all of the…

A: The cytosol of red blood cells contains the oxygen-carrying globular protein hemoglobin, which is…

Q: Two co-op students at your start-up company have been asked to evaluate the rate of reaction…

A: An enzyme is a cellular catalyst that speeds up chemical reactions. Proteins that bind to…

Q: Complex II contains one heme b moiety that is not in the direct path of electron transfer (despite…

A: Hello. Since your question has multiple sub-parts, we will solve the first three sub-parts for you.…

Q: ATP + H₂0 ➜ ADP + Pi 3Na+ (inside) + 2K+ (outside) AG = -30.5kJ/mol + ATP4 + H₂O → 3Na* (outside) +…

A: Gibbs's free energy, known as free energy or G, is a thermodynamic quantity that represents the…

Q: Molecular diameters of proteins IgG and TNFα are 11.2 nm and 4.4 nm, respectively. The  diffusion…

A: Stokes-Einstein equation is the relationship between radius and diffusion coefficient of a substance…

Q: Using the graph data I estimated Slope = 2.8, about the same as the steeper part of the maternal…

A: Hemoglobin (Hb) is composed of 4 polypeptide chains. Adult Hb has 2 alpha chains and 2 beta chains…

Q: Normal Hgb is referred to as HbA and contains 4 subunits, 2 α-globin chains and 2 β-globin chains,…

A: The protein structure has different levels:- Primary structure: refers to the normal amino acid…

Q: In TLC, why are the colors of the peaks for each amino acid are different depending on the types of…

A: TLC stands for Thin Layer Chromatography. It is a refined technique that is used for isolating or…

Q: Bovine ribonuclease folds with ΔH° = -280 kJ mol-1 and ΔS° = -0.79 kJ mol-1 K -1. Assume ΔH° and ΔS°…

A: The basis for predicting spontaneity of a reaction is based on (ΔG), the change in G, at constant T…

Q: The following data describe binding of ligand A to a protein, using both Scatchard plots and Hills…

A: Scatchard plots is used to determine the affinity of the receptor or any protein for its ligand and…

Q: Electrophoresis is performed at PH 6.8 on a mixture of mutated hemoglobin that differ from normal…

A: To determine the order of migration between the cathode and anode of the mutated hemoglobins…

Q: BIM-46187 is a protein inhibitor that binds to the a-subunit of the G. protein. It prevents the…

A: Cell signaling is the conversion of the information in a signal into cellular response. Ligands,…

Q: Certain individuals with mild forms ofβ-thalassemia produce, in addition to normal adulthemoglobin…

A: Haemoglobin lepore is defined as a small group consisting of structurally abnormal haemoglobins…

Q: SARS-CoV-2 Spike protein variant Wuhan Alpha Beta Delta Omicron KD, nM 60 9.6 2.4 1.2 2.4 Using the…

A: Consider a protein 'P' that can bind with 5 different ligands; L1, L2, L3 , L4 and L5.The…

Q: Substrate A has a Km of 45uM and a kcat of 100/s with trypsin and a Km of 540mM and a kcat of 2/s…

A: Enzymes are the proteinous structure that helps in increasing the rate of metabolism. The function…

Q: 33. Band 3 protein exists as a 95-kDa multipass membrane protein that functions as the primary anion…

A: Given,          Band 3 protein ,a protein which is essential for RBC membrane support and also acts…

Q: Dr Merrick is so excited to know the affinity constant Kd values for O2 binding to mammoth OBP and…

A: ANSWER;- It is given that the ka values of OBP and elephants Hb are the same at pH=7. Kd is the…

Q: Calculate the concentration of the ligand required to fill 25% of the binding site.

A: Given, X+A ⇌ XA       , ka = 1.5 ×10-6 Y+A ⇌ YA         , ka = 4.7 × 10-4 Kd = 1Ka So,  Kd for first…

Q: One form of anemia results when individuals have a deficiency in the enzyme phosphatidylinositol…

A: Complement decay-accelerating factor (CD55 or DAF) is a protein that is transcribed and translated…

Q: Describe the concept of isoelectric point and calculate the PI for isoleucine?

A: Isoelectric point is the pH value at which the charge on an amino acid is zero.

Q: Özcan MM. and his colleagues tried to obtain 3 different fatty acids from moringa pelegrina nucleus…

A: Efficiency refers to the amount of the product produced from the source. Here it will expressed in…

Q: The transport of aspirin (pKa = 3.5, structure shown here) from the digestive tract to the…

A: Aspirin is a drug that causes the pH to drop. Its pKa is 3.5, and it works as a weak acid.

Q: Based on the following data, is the p50 higher or lower than normal in (a) hemoglobin Yakima and (b)…

A: P50 is defined as the oxygen tension at which haemoglobin is 50%saturated with oxygen .When…

Q: What is the dominant biochemical activity or molecular interaction that Sickle Cell Anemia…

A: Hemoglobin is an oligomeric conjugated protein with four peptide chains joined by a…

Q: Briefly explain how heme regulates the expression of globin genes in cells that synthesize…

A: Hemoglobin synthesis are global production and heme synthesis. Globin chain production occurs in the…

Q: Erk and P-Erk live in two different locations within the cell even though they are just two…

A: * Mitogen activated protein kinase also called as  MAPK and  p42MAPK, and ERK2 * It is an enzyme…

Q: What effect does a negative effector have on the graph of reac- tion rate (V) vs. [substrate] for an…

A: INTRODUCTION : Allosteric enzymes : Allosteric enzymes are those enzymes which have an additional…

Q: Given a tripeptide Cys-His-Lys, Cys: Pk1 = 1.5; Pk2 = 10.8; PkR = 8.5 His: Pk1 = 1.6; Pk2 = 9.0; PkR…

A: Hi. Thank you for the question, As per the honor code, we are allowed to answer three sub-parts at a…

Q: For the following problem, indicate whether enzyme is repressed (-) or produced (+). Please show all…

A: The lac operon is a set of genes that are used in the metabolism of lactose in E. coli.  The operon…

Q: In a molecular disease of hemoglobin, Hemoglobin Rainier, Tyr 145β is replaced by Cys, which forms a…

A: Hemoglobin is a protein present in the red blood cell. The hemoglobin function is to transport the…

Q: 1. The shape of hemoglobin binding curves is: hyperbolic or sigmoidal 2. a) Based on the binding…

A: Note: As per the guidelines, i could solve only the first three subparts of the question. Please re…

Q: 6c) In the cell in which the Iron Response Factor (IRF) protein is mutated so that it binds to its…

A: Iron regulatory factor (IRF) is a cytoplasmic protein that detects the intracellular iron level and…

Q: A one-to-one protein (P)-ligand (L) complexation (P + L PL) has a equilibrium constant (Kd) value…

A: ∆Cp is the heat capacity at constant pressure. ∆S is change in entropy, degree of randomness. At…

Q: Given the following information, which protein would be most difficult to isolate from protein X…

A: Salting out is a method of separation of protein mixtures that is based on protein solubility. The…

Q: Can you check if A is correct and please help answer the following questions?

A: Histidine: It is an amino acid that contains a carboxylic acid,α amino group, and an imidazole side…

Q: bu generate mutants in the metabolic pathway for starlase. You conduct some complementation sts…

A: A complementation test is used to determine whether two mutations present at the same locus or at…

Q: The ABO blood group antigens are the terminal sugars covalently linked to the end of the glycolipid…

A: Antigens are substances that are generated by the immune system.  These antigens can be present in…

Q: You have discovered a new hemoglobin variant you are calling Hb-21. You have noticed the following…

A: Option C is the Correct Answer Reason- According to the bohr effect when pH of Blood increases then…