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From the data, what can you conlucde about the effect of this mutant?

From the data, what can you conlucde about the effect of this mutant?

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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A physician has identified a mutant version of PAH that causes a mild form of PKU. You measure the activity of PAH as you increase the concentration of BH4. Data are shown for the WT (red) and mutant (blue) forms of PAH in the graph below. Activity uMol L-Tyrosine/min_mg) 2.0 1.5- 0.5- 0.0- 50 100 [BH4] (UM) 150 200 From the data, what can you conlucde about the effect of this mutant?
Transcribed Image Text:A physician has identified a mutant version of PAH that causes a mild form of PKU. You measure the activity of PAH as you increase the concentration of BH4. Data are shown for the WT (red) and mutant (blue) forms of PAH in the graph below. Activity uMol L-Tyrosine/min_mg) 2.0 1.5- 0.5- 0.0- 50 100 [BH4] (UM) 150 200 From the data, what can you conlucde about the effect of this mutant?
you conlucde about the effect of this mutant? This mutation decreases the affinity of PAH for BH4. This mutation increases the affinity of PAH for BH4. This mutation has no effect on PAH. This mutation decreases the reaction velocity even when saturated with BH4.
Transcribed Image Text:you conlucde about the effect of this mutant? This mutation decreases the affinity of PAH for BH4. This mutation increases the affinity of PAH for BH4. This mutation has no effect on PAH. This mutation decreases the reaction velocity even when saturated with BH4.
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