Answered: Feedback loops regulate the release of…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Feedback loops regulate the release of hormones in either a positive or negative 上二三一三 I loop. Consider this example: The hypothalamus releases thyrotropin-releasing hormone (TRH), which stimulates the pituitary to release the TSH (thyroid-stimulating hormone). TSH then stimulates thyroid gland to release thyroid hormone. When elevated levels of thyroid hormone are detected by the hypothalamus and pituitary further release of TRH and TSH is suppressed. B. What would happen to the levels of TRH and TSH if a tumor of the thyroid gland were discovered resulting in uncontrolled release of the thyroid hormone from the tumor itself?

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Well conventionally speaking, if T3/T4 rises due to a thyroid tumour, it logically means that TSH/TRH would decrease, but that is not the case. The hormone produced by the neoplastic thyroid cells are not true/ purely functional. They fail to exert a negative feedback on hypothalamus or pituitary so much so that the hypothalamus and pituitary doesn't detect thyroid hormones at all resulting in excessive release of TRH and TSH.

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