Does the inhibition of TRH via negative feedback occur after the secretion of TSH or after the secretion of IGF? Ik that inhibition of TRH via negative feedback usually occurs after TSH in the thyroid pathway. But TSH and GH Are both secreted from the anterior pituitary gland so idk what to do?
Does the inhibition of TRH via negative feedback occur after the secretion of TSH or after the secretion of IGF?
Ik that inhibition of TRH via negative feedback usually occurs after TSH in the thyroid pathway. But TSH and GH Are both secreted from the anterior pituitary gland so idk what to do?
The synthesis of all endocrine hormones is governed by the secretions of the anterior pituitary gland, which in turn is under the control of secretions from the hypothalamus (also known as the master gland).
The thyroid releasing hormone (TRH) secreted by the hypothalamus acts on the anterior pituitary glands and stimulates the secretion of thyroid-stimulating hormones (TSH). The thyroid stimulation hormone then acts on the thyroid gland (the target organ for TSH) and triggers thyroid hormone production (T3 and T4). The increased levels of thyroid hormones (mostly the T3 hormone) initiate a negative feedback loop and inhibit TRH and TSH production from the hypothalamus and anterior pituitary gland, respectively. The secretion of growth hormone (GH) from the anterior pituitary gland, which in turn regulates the secretion of IGF (insulin-like growth factor), is not governed by the secretion of TRH, and these hormones do not have any role in the inhibition of TRH via the negative feedback loop.
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