Excessive alcohol consumption can damage liver cells, leading to cirrhosis (liver scarring) and cell death. Hyperammonemia (elevated blood NH4+) is a common side effect of cirrhosis, as impaired hepatocyte function leads to less ammonia processed through the urea cycle. The ammonia is instead shunted around the liver and into circulation. Which of the following treatments, performed to the remaining healthy cells in a cirrhotic liver, might help relieve hyperammonemia? (A) inhibit carbamoyl phosphate synthase I (B) increase the activity of ornithine transcarbamoylase (C) introduce a molecule that sequesters ornithine and diverts it to excretion in the urine (D) stimulate the transamination of aspartate into oxaloacetate for use in gluconeogenesis (E) lower blood pH in an effort to activate the blood’s carbonic acid buffering system
Excessive alcohol consumption can damage liver cells, leading to cirrhosis (liver scarring) and cell death. Hyperammonemia (elevated blood NH4+) is a common side effect of cirrhosis, as impaired hepatocyte function leads to less ammonia processed through the urea cycle. The ammonia is instead shunted around the liver and into circulation.
Which of the following treatments, performed to the remaining healthy cells in a cirrhotic liver, might help relieve hyperammonemia?
(A) inhibit carbamoyl phosphate synthase I
(B) increase the activity of ornithine transcarbamoylase
(C) introduce a molecule that sequesters ornithine and diverts it to excretion in the urine (D) stimulate the transamination of aspartate into oxaloacetate for use in gluconeogenesis (E) lower blood pH in an effort to activate the blood’s carbonic acid buffering system
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