each heavy chain and each light chain has two functional areas: consists of highly variable amino acid sequences which forms the basis of antibody specificity; antigen binds here ????? more conserved amino acid sequences; ????? there are five basic sequences of amino acids, which define the 5 antibody classes (IgG, IgA, IgM, IgE and IgD);
each heavy chain and each light chain has two functional areas: consists of highly variable amino acid sequences which forms the basis of antibody specificity; antigen binds here ????? more conserved amino acid sequences; ????? there are five basic sequences of amino acids, which define the 5 antibody classes (IgG, IgA, IgM, IgE and IgD);
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:eds
Antibodies (Immunoglobulins)
Objective 14
Antibodies (immunoglobulins) are glycoproteins secreted by plasma cells. They are
located in interstitial fluid, plasma (gamma globulin fraction) and in body secretions.
onse
A.
Antibody Structure
Heavy chain
Antigen-binding
site
Light chain
Insmakamos
Hinge region
Complement-
binding site
Stem region
Macrophage
binding site
OHO
(a) Antibody molecule
OHO
X = Disulfide bond
Carbohydrate
four polypeptide chains (two heavy, two light)
chains are held together by covalent disulfide bonds (S=S)
each heavy chain and each light chain has two functional areas:
consists of highly variable amino acid
sequences which forms the basis of
antibody specificity; antigen binds here
?????
to
more conserved amino acid sequences;
there are five basic sequences of amino acids,
which define the 5 antibody classes (IgG, IgA,
IgM, IgE and IgD);
?????
each class has its own characteristic set of
effector functions (see next page)
Your notes:
4 40
4. 39
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